عنوان

Agent-Based Modeling in Molecular Systems Biology.

Number

LA8jr5j73x

Title Proper

Agent-Based Modeling in Molecular Systems Biology.

General Material Designation

[Article]

First Statement of Responsibility

Soheilypour, MohammadMofrad, Mohammad RK

Text of Note

Molecular systems orchestrating the biology of the cell typically involve a complex web of interactions among various components and span a vast range of spatial and temporal scales. Computational methods have advanced our understanding of the behavior of molecular systems by enabling us to test assumptions and hypotheses, explore the effect of different parameters on the outcome, and eventually guide experiments. While several different mathematical and computational methods are developed to study molecular systems at different spatiotemporal scales, there is still a need for methods that bridge the gap between spatially-detailed and computationally-efficient approaches. In this review, we summarize the capabilities of agent-based modeling (ABM) as an emerging molecular systems biology technique that provides researchers with a new tool in exploring the dynamics of molecular systems/pathways in health and disease.

Date of Publication

2018

Title

UC Berkeley

Electronic name

[Article]

277469

a

Y