عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TL7cj5n71d
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
The Regulation of BMP Signaling in Mouse Embryonic Stem Cells and Early Mouse Embryogenesis
General Material Designation
[Thesis]
First Statement of Responsibility
Luong, Mui Nhuc
Subsequent Statement of Responsibility
Cho, Ken WY
.PUBLICATION, DISTRIBUTION, ETC
Date of Publication, Distribution, etc.
2014
DISSERTATION (THESIS) NOTE
Body granting the degree
Cho, Ken WY
Text preceding or following the note
2014
SUMMARY OR ABSTRACT
Text of Note
Understanding the molecular mechanisms that govern animal development is one of the major challenges in developmental biology. The TGF-β members such as the bone morophogenetic proteins (BMP) play critical and diverse roles throughout embryonic development in both vertebrates and invertebrates and understanding the mechanisms by which they initiate specific cellular differentiation programs and control of gene expression is important. This dissertation will focus on the characterization of the BMP responsive element (BRE) identified in our lab. Additionally, I will demonstrate that the BRE functions as an activator in BRE-mediated BMP signaling and is responsible for modulating a subset of BMP target genes in mouse embryonic stem (ES) cells. To complement our in vitro studies, our lab also investigated the role of BMPs in early mouse embryonic development. Our studies reveal that BMP signaling may be active in the inner cell mass (ICM) during mouse embryogenesis and is playing a role in sustaining pluriopotency by interacting with the Oct4/Sox2/Nanog network.
PERSONAL NAME - PRIMARY RESPONSIBILITY
Paley, Miranda Amelia
PERSONAL NAME - SECONDARY RESPONSIBILITY
Luong, Mui Nhuc
CORPORATE BODY NAME - SECONDARY RESPONSIBILITY
UC Irvine
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
