عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TL7789p31n
LANGUAGE OF THE ITEM
.Language of Text, Soundtrack etc
انگلیسی
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Divergent role of Gs alpha subunit in CD4 T cells on Th subset differentiation and their inflammatory profile
General Material Designation
[Thesis]
First Statement of Responsibility
Goldstone, Jonathan
.PUBLICATION, DISTRIBUTION, ETC
Date of Publication, Distribution, etc.
2011
DISSERTATION (THESIS) NOTE
Text preceding or following the note
2011
SUMMARY OR ABSTRACT
Text of Note
Cyclic AMP both inhibits and promotes T cell functions; however the effects in a particular T helper subset have been difficult to define. We engineered mice with a deletion of the stimulatory G alpha subunit (Gnas-/-) in CD4⁺ T cells. Gnas-/- CD4 T cells have reduced cAMP accumulation, display weak Th17 and Th1 but normal Th2 responses and fail to elicit colitis. Incubation of Gnas-/ - CD4 T cells with cell permeable cAMP analog restored their impaired phenotype via a PKA-dependent influx of Ca²⁺. These findings define an important role for cAMP in the differentiation of certain Th subsets and their subsequent inflammatory functions and raise the possibility that altering cAMP levels in CD4 T cells could provide an immunomodulatory approach for specific Th subsets
PERSONAL NAME - PRIMARY RESPONSIBILITY
Bowman, Rocco
PERSONAL NAME - SECONDARY RESPONSIBILITY
Goldstone, Jonathan
CORPORATE BODY NAME - SECONDARY RESPONSIBILITY
UC San Diego
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
