3.3.1 Hematopoietic Stem Cells3.3.2 Mesenchymal Stem Cells; 3.4 Sources for Perinatal Stem Cell Derivation; 3.4.1 Umbilical Cord; 3.4.2 Umbilical Cord Blood; 3.4.3 Amniotic Fluid; 3.4.4 Amnion; 3.4.5 Placental Tissue; 3.5 Stemness of Perinatal Stem Cells; 3.6 Conclusions and Perspectives; References; 4: Quality Assessment of Umbilical Cord Tissue in Newborn Stem Cell Banking; 4.1 Newborn Stem Cell Banking; 4.2 Umbilical Cord Tissue Banking; 4.3 Quality Assessment of Umbilical Cord Tissue; 4.4 Incorporation of Quality Assessment into Umbilical Cord Tissue Banking
Text of Note
4.5 Regulatory Considerations4.6 Conclusion; References; 5: Safety and Genetic Stability of Cultured Perinatal Mesenchymal Stem Cells; 5.1 Safety Analysis of Perinatal Mesenchymal Stem Cells in Preclinical Studies; 5.2 Safety Evaluation of Perinatal Mesenchymal Stem Cells in Clinical Trials; 5.3 Potential Safety Concerns and Genetic Stability; 5.4 Future Studies for Safer Clinical Application of Perinatal Mesenchymal Stem Cells; References; 6: Therapeutic Application of Perinatal Mesenchymal Stem Cells in Nervous System Diseases; 6.1 Introduction
Text of Note
6.2 Preclinical Studies of Perinatal Mesenchymal Stem Cell Therapy for Nervous System Diseases6.2.1 Perinatal Mesenchymal Stem Cells for Stroke; 6.2.1.1 Umbilical Cord Mesenchymal Stem Cells (UC-MSC); 6.2.1.2 Umbilical Cord Blood Mesenchymal Stem Cells (UCB-MSC); 6.2.1.3 Amniotic Membrane or Fluid Mesenchymal Stem Cells (AM/AF-MSC); 6.2.1.4 Placenta Mesenchymal Stem Cells (P-MSC); 6.2.2 Perinatal Mesenchymal Stem Cells for Spinal Cord Injury (SCI); 6.2.3 Perinatal Mesenchymal Stem Cells for Parkinson's Disease (PD); 6.2.4 Perinatal Mesenchymal Stem Cells for Alzheimer's Disease
0
8
8
8
8
SUMMARY OR ABSTRACT
Text of Note
This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury. Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton's Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.