عنوان

Target organ toxicology in Caenorhabditis elegans /

(Number (ISBN

9789811360107

(Number (ISBN

9789811360114

(Number (ISBN

9811360103

(Number (ISBN

9811360111

Erroneous ISBN

9789811360091

Erroneous ISBN

981136009X

Title Proper

Target organ toxicology in Caenorhabditis elegans /

General Material Designation

[Book]

First Statement of Responsibility

Dayong Wang.

Place of Publication, Distribution, etc.

Singapore :

Name of Publisher, Distributor, etc.

Springer,

Date of Publication, Distribution, etc.

[2019]

Specific Material Designation and Extent of Item

1 online resource

Text of Note

Includes bibliographical references.

Text of Note

Intro; Preface; Contents; Chapter 1: Protective Responses of Different Organs to Environmental Toxicants or Stresses; 1.1 Introduction; 1.2 Protective Responses to Environmental Toxicants or Stresses in the Intestine; 1.2.1 Superoxide Dismutase (SOD) Proteins; 1.2.2 MTL-1 and MTL-2; 1.2.3 Heat Shock Proteins (HSPs); 1.2.4 PMK-1, SKN-1/Nrf, and GST-4; 1.2.5 Transcriptional Factor DAF-16; 1.2.6 Antimicrobial Proteins; 1.2.7 Mitochondrial Unfolded Protein Response (UPR); 1.2.8 Endoplasmic Reticulum (ER) UPR; 1.2.9 Autophagy

Text of Note

1.3 Protective Responses to Environmental Toxicants or Stresses in Epidermis1.3.1 Antimicrobial Proteins; 1.3.2 Autophagy; 1.4 Protective Responses to Environmental Toxicants or Stresses in Neurons; 1.4.1 SKN-1/Nrf; 1.4.2 JNK Signaling; 1.4.3 ERK Signaling; 1.4.4 Antimicrobial Proteins; 1.4.5 Autophagy; 1.5 Protective Responses to Environmental Toxicants or Stresses in Muscle; 1.6 Perspectives; References; Chapter 2: Avoidance Behavior of Nematodes to Environmental Toxicants or Stresses; 2.1 Introduction

Text of Note

2.2 Neurons Involved in the Regulation of Avoidance Behavior to Environmental Toxicants or Stress2.2.1 ASH Sensory Neurons; 2.2.1.1 Involvement of ASH Sensory Neurons in Response to Environmental Toxicants or Stresses; 2.2.1.2 Molecular Basis for ASH Sensory Neurons in Response to Environmental Toxicants or Stresses; 2.2.1.2.1 G Proteins; 2.2.1.2.2 Seven-Transmembrane Protein DCAR-1; 2.2.1.2.3 Neurotransmitter Signals; 2.2.2 ADL Sensory Neurons; 2.2.2.1 Involvement of ADL Sensory Neurons in Response to Environmental Toxicants or Stresses

Text of Note

2.2.2.2 Molecular Basis for ADL Sensory Neurons in Response to Environmental Toxicants or Stresses2.2.3 ASK Sensory Neurons; 2.2.4 ASJ Sensory Neurons; 2.2.4.1 Involvement of ASJ Sensory Neurons in Response to Environmental Toxicants or Stresses; 2.2.4.2 Molecular Basis for ASJ Sensory Neurons in Response to Environmental Toxicants or Stresses; 2.2.5 ADF Sensory Neurons; 2.2.6 ASI Sensory Neurons; 2.2.7 AWB Sensory Neurons; 2.2.8 AWC Sensory Neurons; 2.2.9 BAG Sensory Neurons; 2.2.9.1 Involvement of BAG Sensory Neurons in Response to Environmental Toxicants or Stresses

Text of Note

2.2.9.2 Molecular Basis for BAG Sensory Neurons in Response to Environmental Toxicants or Stresses2.2.10 OLL Sensory Neurons; 2.2.11 Interneurons; 2.3 Neuronal Circuit for the Avoidance Behavior to Environmental Toxicants or Stresses and the Underlying Molecular Basis; 2.3.1 ASI-ADF-ASH and ASH-RIC-ASI Neuronal Circuits; 2.3.1.1 ASI-ADF-ASH Neuronal Circuit; 2.3.1.2 ASH-RIC-ASI Neuronal Circuit; 2.3.1.3 Cross-Inhibitory Neural Circuitry Between ASHs and ASIs; 2.3.2 ADL-AIB Neuronal Circuit; 2.3.3 ASJ-RIM/RIC Neuronal Circuit; 2.3.4 AWB-AIZ/RMG Neuronal Circuit; 2.3.5 OLL-RMG Neuronal Circuit

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Text of Note

This book introduces readers to intestinal and epidermal barriers, and to toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans. In addition, it discusses the protective responses of various organs and nematodes' avoidance behaviour with regard to environmental toxicants or stresses. The intestinal, epidermal, neuronal, and germline signalling pathways required for the regulation of toxicity of environmental toxicants or stresses are also introduced and discussed. As a classic model animal with well-described genetic and developmental backgrounds, the nematode Caenorhabditis elegans has been successfully and widely used in both toxicity assessments and toxicological studies on various environmental toxicants and stresses. Once exposure to certain environmental toxicants has occurred, the toxicants can enter into the primary targeted organs (such as intestinal cells), and even be translocated into secondary targeted organs (such as reproductive organs and neurons). Based on related available data, this book provides a systematic understanding of target organ toxicology in C. elegans.

Source for Acquisition/Subscription Address

Springer Nature

Stock Number

com.springer.onix.9789811360107

Title

Target organ toxicology in Caenorhabditis elegans.

International Standard Book Number

9789811360091

Caenorhabditis elegans-- Toxicology.

Target organs (Anatomy)

SCIENCE-- Life Sciences-- Zoology-- General.

Target organs (Anatomy)

MKG

MMG

SCI-- 070000

Number

Edition

Class number

Wang, Dayong

Date of Transaction

20200823233711.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y