عنوان

Progranulin and central nervous system disorders /

(Number (ISBN

9789811361869

(Number (ISBN

9789811361876

(Number (ISBN

9789811361883

(Number (ISBN

981136186X

(Number (ISBN

9811361878

(Number (ISBN

9811361886

Erroneous ISBN

9789811361852

Erroneous ISBN

9811361851

Title Proper

Progranulin and central nervous system disorders /

General Material Designation

[Book]

First Statement of Responsibility

Hideaki Hara [and 4 others], editors.

Place of Publication, Distribution, etc.

Singapore :

Name of Publisher, Distributor, etc.

Springer,

Date of Publication, Distribution, etc.

2019.

Specific Material Designation and Extent of Item

1 online resource

Text of Note

Molecular and functional properties of progranulin -- Progranulin as a potential biomarker of central nervous system disease -- Progranulin and frontotemporal lobar degeneration -- PGRN and neurodegenerative dieseases other than FTLD -- Progranulin regulations of lysosomal homeostatis and its involvement in neurodegenerative diseases -- Progranulin in sexual differentiation of the developing brain -- Progranulin and inflammation/neuroinflammation -- Neural stem/progenitor cells and progranulin -- Generationa nd phenotyping of progranulin-deficient mice -- Pleiotropic protective effects of progranulin in the treatment of ischemic stroke -- New therapeutic appraoches against ocular diseases.

0

Text of Note

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.

Source for Acquisition/Subscription Address

Springer Nature

Stock Number

com.springer.onix.9789811361869

Title

Progranulin and central nervous system disorders.

International Standard Book Number

9789811361852

Glycoproteins.

Neurogenetics.

Proteins.

Glycoproteins.

Neurogenetics.

Proteins.

SCIENCE-- Life Sciences-- Biochemistry.

MFN

MFN

SCI-- 007000

Number

Edition

Class number

Book number

Hara, Hideaki

Hosokawa, Masato.

Nakamura, Shinsuke.

Nishihara, Masugi.

Shimohata, Takayoshi.

Date of Transaction

20200823233524.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y