عنوان

Synthesis of therapeutic oligonucleotides /

(Number (ISBN

9789811319129

(Number (ISBN

981131912X

Erroneous ISBN

9789811319112

Erroneous ISBN

9811319111

Title Proper

Synthesis of therapeutic oligonucleotides /

General Material Designation

[Book]

First Statement of Responsibility

Satoshi Obika, Mitsuo Sekine, editors.

Place of Publication, Distribution, etc.

Singapore :

Name of Publisher, Distributor, etc.

Springer,

Date of Publication, Distribution, etc.

2018.

Specific Material Designation and Extent of Item

1 online resource

Text of Note

Includes bibliographical references.

Text of Note

Intro; Preface; Contents; Part I: Synthesis of Natural Oligonucleotides; Non-protected Synthesis ofOligonucleotides; 1 Introduction; 2 Development ofProton-Block Strategy fortheSynthesis ofOligonucleotides WithoutBase Protection; 3 Development oftheActivated Phosphite Method Using N-Unprotected Phosphoramidites; 4 Mechanism oftheActivated Phosphite Method; 5 Synthesis ofRNA Oligomers Using theActivated Phosphite Method; 6 Synthesis ofPhosphoramidite Monomer Building Blocks; 7 Conclusion; References

Text of Note

10 RNA Synthesis Using [[2-(Methylthio)phenyl]thio]methyl (MPTM) Group11 RNA Synthesis Using (N-Dichloroacetyl-N-methyl)aminobenzyloxylmethyl (DCMABOM) Group; 12 RNA Synthesis Using theAcetal Levulinyl Ester (ALE) Group; 13 RNA Synthesis Using theCyanoethyl (CE) Group; 14 RNA Synthesis Without Using Base Protection; 15 Recent Studies onRNA Chemical Synthesis; 16 Summary andPerspectives; References; RNA Synthesis Using theCEM Group; 1 Introduction; 2 Synthesis ofCEM Amidites; 3 Synthesis ofRNA; 4 Experimental Section; 4.1 Preparation ofCEM-SMe

Text of Note

3 Current RNA Synthesis Using TBDMS as2'-Hydroxyl Protecting Group4 RNA Synthesis Using Acid-Labile 2'-Hydroxyl Protecting Groups; 5 RNA Synthesis Using 2'-Protecting Groups Having anAcetal Skeleton; 5.1 (2-Nitrobenzyl)oxymethyl (NBOM) Group; 5.2 2-(Trimethylsilyl)ethoxymethyl (SEM) Group; 6 RNA Synthesis Using theTriisopropylsilyloxymethyl (Tom) Group; 7 Cyanoethoxy-1-Methylethyl (CEE) andCyanoethoxymethyl (CEM) Groups; 8 RNA Synthesis Using 4-Methylphenylsulfonylethoxymethyl (TEM) Group; 9 RNA Synthesis Using tert-Butyldithiomethyl (DTM) Group

Text of Note

4.2 Synthesis ofU-CEM Phosphoramidite (5a.)4.2.1 32 52 O-(Tetraisopropyldisiloxane-1,3-diyl)-22 O-(2-cyanoethoxymethyl)uridine (2a.); 4.2.2 22 O-(2-Cyanoethoxymethyl)uridine (3a.); 4.2.3 52 O-(4,42 Dimethoxytrityl)-22 O-(2-xyanoethoxymethyl)uridine (4a.); 4.2.4 52 O-(4,42 Dimethoxytrityl)-22 O-(2-cyanoethoxymethyl)uridine 32 O-(2-Cyanoethyl N, N-diisopropylphosphoramidite) (5a.); 4.3 Synthesis ofC-CEM Phosphoramidite (5b.); 4.3.1 4-N-Acetyl-32 52 O-(tetraisopropyldisiloxane-1,3-diyl)-22 O-(2-cyanoethoxymethyl)cytidine (2b.); 4.3.2 4-N-Acetyl-22 O-(2-cyanoethoxymethyl)cytidine (3b.)

Text of Note

Various Coupling Agents inthePhosphoramidite Method forOligonucleotide Synthesis1 Introduction; 2 Coupling Agents inthePhosphoramidite Method; 2.1 1H-Tetrazole andIts Derivatives; 2.1.1 1H-Tetrazole; 2.1.2 5-Ethylthio-1H-tetrazole; 2.1.3 5-Benzylthio-1H-tetrazole; 2.1.4 5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetrazole (Activator 42); 2.2 4,5-Dicyanoimidazole; 2.3 Carboxylic Acids; 2.4 Acid/Azole Complexes; 3 Conclusion; References; Recent Development ofChemical Synthesis ofRNA; 1 Introduction; 2 Basic Principle ofSolid-Phase Synthesis ofDNA/RNA inPhosphoramidite Approach

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Text of Note

This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.

Source for Acquisition/Subscription Address

Springer Nature

Stock Number

com.springer.onix.9789811319129

Title

Synthesis of therapeutic oligonucleotides.

International Standard Book Number

9789811319112

Oligonucleotides.

Oligonucleotides-- chemical synthesis.

Oligonucleotides-- therapeutic use.

Oligonucleotides.

SCIENCE-- Life Sciences-- Biochemistry.

SCI-- 007000

TDC

TDCW

Number

Edition

Class number

Class number

Class number

Obika, Satoshi

Sekine, Mitsuo

Date of Transaction

20200823225825.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y