عنوان
پدید آورنده
موضوع
رده
QH447
QH447
کتابخانه
محل استقرار
INTERNATIONAL STANDARD BOOK NUMBER
(Number (ISBN
9789811310706
(Number (ISBN
9789811310713
(Number (ISBN
9789811310720
(Number (ISBN
9789811345616
(Number (ISBN
981131070X
(Number (ISBN
9811310718
(Number (ISBN
9811310726
(Number (ISBN
9811345619
Erroneous ISBN
9789811310706
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Applied computational genomics /
General Material Designation
[Book]
First Statement of Responsibility
Yin Yao, editor.
EDITION STATEMENT
Edition Statement
Second edition.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Singapore :
Name of Publisher, Distributor, etc.
Springer,
Date of Publication, Distribution, etc.
2018.
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
1 online resource
SERIES
Series Title
Translational bioinformatics,
Volume Designation
volume 13
ISSN of Series
2213-2775 ;
CONTENTS NOTE
Text of Note
Intro; Contents; Contributors; Chapter 1: Introduction; 1.1 Overview; 1.2 Overview ofChapter Contents; References; Chapter 2: Exploring Polygenic Overlap Between ADHD andOCD; 2.1 Introduction; 2.2 Polygenic Risk Score Analyses; 2.3 Protein-Protein Link Evaluation; 2.4 Expression Quantitative Trait Locus (eQTL) Analysis; 2.5 Meta-analysis; 2.6 Discussion; References; Web Resources; Chapter 3: Concepts ofGenetic Epidemiology; 3.1 Introduction: Genetic Epidemiology; 3.1.1 Family Studies; 3.1.2 Twin Studies; 3.1.3 Adoption Studies; 3.1.4 Migration Studies.
Text of Note
3.2 Applications ofGenetic Epidemiology toGene Identification3.2.1 Samples; 3.2.2 Selection ofControls; 3.2.3 Risk Estimation; 3.2.4 Identification ofEnvironmental Factors; 3.3 Applications, Impact, andFuture Directions; References; Chapter 4: Rare Variant Analysis inUnrelated Individuals; 4.1 Introduction; 4.1.1 Success ofGWAS andIts Limitation; 4.1.2 Detecting Rare Variants; 4.2 Data Description andMethods; 4.2.1 Data Describe; 4.2.2 Methods; 4.2.2.1 Collapsing Method; 4.2.2.2 Combined Multivariate andCollapsing; 4.2.2.3 Weighted Sum Association Method (WSM).
Text of Note
4.2.2.4 Pooled Association Tests forRare Variants4.2.2.5 A Data-Adaptive Sum Test (Consider theDirection); 4.2.2.6 Alpha Test; 4.2.2.7 Sequence Kernel Association Test (SKAT); 4.2.2.8 A General Framework forDetecting Disease Associations withRare Variants inSequencing Studies; 4.2.2.9 Haplotype-Based Collapsing Test; 4.2.2.10 Odds Ratio Weighted Sum Statistic (ORWSS); 4.2.2.11 Combining Related andUnrelated Individual Together toDetect Rare Variants; 4.3 Discussion; References; Chapter 5: Whole-Genome Association Analysis of Treatment Response from Obsessive-Compulsive Disorder.
Text of Note
5.1 Introduction5.2 Material andMethods; 5.3 Statistical Methods; 5.4 Results; 5.5 Discussion; References; Chapter 6: QTL Mapping ofMolecular Traits forStudies ofHuman Complex Diseases; 6.1 Introduction; 6.1.1 Genome-Wide Association Study andIts Limitation; 6.1.2 Functionality ofGenetic Variants; 6.1.3 QTL Mapping andGenetic Variants; 6.2 QTL Mapping ofMolecular Traits; 6.2.1 eQTL; 6.2.1.1 Experimental Platforms; 6.2.1.2 RNA Quality; 6.2.1.3 Sample Heterogeneity; 6.2.1.4 Sample Size; 6.2.1.5 Covariates; 6.2.1.6 Analytical Procedures; 6.2.1.7 Significance Criteria; 6.2.2 mQTL.
Text of Note
6.3 Other Types ofQuantitative Traits6.4 Software andAlgorithm forQTL Mapping; 6.5 Applications ofQTL Mapping inGenetic Studies ofComplex Diseases; 6.6 Database or QTL Mapping Results; References; Chapter 7: From Family Study to Population Study: A History of Genetic Mapping for Nasopharyngeal Carcinoma (NPC); 7.1 Introduction; 7.2 The Working Model; 7.3 Candidate-Gene Association Studies; 7.3.1 Apoptosis andCell Cycle Arrest Pathways; 7.3.2 Carcinogen Metabolism andDetoxification Pathways; 7.3.3 DNA Repair Pathways; 7.3.4 Cytokines andGrowth Factors; 7.3.5 Cell Adhesion.
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SUMMARY OR ABSTRACT
Text of Note
The volume provides a review of statistical development and application in the area of human genomics, including candidate gene mapping, linkage analysis, population-based genome-wide association, exon sequencing, and whole genome sequencing analysis. The authors are extremely experienced in the field of statistical genomics and will give a detailed introduction to the evolution of the field, as well as critical comments on the advantages and disadvantages of the proposed statistical models. The future directions of translational biology will also be described.
OTHER EDITION IN ANOTHER MEDIUM
International Standard Book Number
9789811310706
TOPICAL NAME USED AS SUBJECT
Bioinformatics.
Genomics-- Mathematics.
Bioinformatics.
Biotechnology.
Medical genetics.
Molecular biology.
SCIENCE-- Life Sciences-- Biochemistry.
(SUBJECT CATEGORY (Provisional
MFN
MFN
SCI-- 007000
DEWEY DECIMAL CLASSIFICATION
Number
572
.
8/6
Edition
23
LIBRARY OF CONGRESS CLASSIFICATION
Class number
QH447
PERSONAL NAME - ALTERNATIVE RESPONSIBILITY
Yao, Yin
ORIGINATING SOURCE
Date of Transaction
20200823224444.0
Cataloguing Rules (Descriptive Conventions))
pn
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب [Book]
Y
