عنوان

Total synthesis of natural products with antimicrobial activity /

(Number (ISBN

9789811088063

(Number (ISBN

9811088063

Erroneous ISBN

9789811088056

Erroneous ISBN

9811088055

Title Proper

Total synthesis of natural products with antimicrobial activity /

General Material Designation

[Book]

First Statement of Responsibility

Andrew Giltrap.

Place of Publication, Distribution, etc.

Singapore :

Name of Publisher, Distributor, etc.

Springer,

Date of Publication, Distribution, etc.

2018.

Specific Material Designation and Extent of Item

1 online resource (xxiv, 268 pages) :

Other Physical Details

illustrations (some color)

Series Title

Springer theses,

ISSN of Series

2190-5053

Text of Note

Introduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental.

0

Text of Note

This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.

International Standard Book Number

9789811088056

Anti-infective agents.

Clinical biochemistry.

Natural products.

Pharmaceutical chemistry.

Chemistry.

Drug Resistance.

Medical Biochemistry.

Medicinal Chemistry.

Anti-infective agents.

Clinical biochemistry.

MEDICAL-- Pharmacology.

Natural products.

Pharmaceutical chemistry.

MED-- 071000

PSB

Number

Edition

Class number

Giltrap, Andrew

Date of Transaction

20200823223019.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y