عنوان

Statistical methods for survival trial design :

(Number (ISBN

0429470177

(Number (ISBN

0429892942

(Number (ISBN

9780429470172

(Number (ISBN

9780429892943

Erroneous ISBN

1138033227

Erroneous ISBN

9781138033221

Title Proper

Statistical methods for survival trial design :

General Material Designation

[Book]

Other Title Information

with applications to cancer clinical trials using R /

First Statement of Responsibility

Jianrong Wu.

Place of Publication, Distribution, etc.

Boca Raton :

Name of Publisher, Distributor, etc.

CRC Press, Taylor & Francis,

Date of Publication, Distribution, etc.

[2018]

Date of Publication, Distribution, etc.

©2018

Specific Material Designation and Extent of Item

1 online resource.

Series Title

Chapman & Hall/CRC biostatistics series

Text of Note

Includes bibliographical references and index.

Text of Note

Chapter 1 Introduction to Cancer Clinical Trials -- chapter 2 Survival Analysis -- chapter 3 Counting Process and Martingale -- chapter 4 Survival Trial Design under the Parametric Model -- chapter 5 Survival Trial Design under the Proportional Hazards Model -- chapter 6 Survival Trial Design under the Cox Regression Model -- chapter 7 Complex Survival Trial Design -- chapter 8 Survival Trial Design under the Mixture Cure Model -- chapter 9 A General Group Sequential Procedure -- chapter 10 Sequential Survival Trial Design -- chapter 11 Sequential Survival Trial Design Using Historical Controls -- chapter 12 Some Practical Issues in Survival Trial Design -- chapter A. Likelihood Function for the Censored Data -- chapter B. Probability of Failure under Uniform Accrual -- chapter C C. Verification of the Minimum Sample Size Conditions -- chapter D.R Codes for the Sample Size Calculations -- chapter E. Derivation of the Asymptotic Distribution -- chapter F. Derivation of Equations for Chapter 8.

0

Text of Note

Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint. Traditional cancer trial designs with time-to-event endpoints are often limited to the exponential model or proportional hazards model. In practice, however, those model assumptions may not be satisfied for long-term survival trials. This book is the first to cover comprehensively the many newly developed methodologies for survival trial design, including trial design under the Weibull survival models; extensions of the sample size calculations under the proportional hazard models; and trial design under mixture cure models, complex survival models, Cox regression models, and competing-risk models. A general sequential procedure based on the sequential conditional probability ratio test is also implemented for survival trial monitoring. All methodologies are presented with sufficient detail for interested researchers or graduate students.

Title

Statistical methods for survival trial design : with applications to cancer clinical trials using R.

International Standard Book Number

9781138033221

Cancer-- Research-- Methodology.

Clinical trials-- Statistical methods.

Medicine-- Research-- Methodology.

R (Computer program language)

Clinical Trials as Topic-- methods.

Neoplasms-- therapy.

Research Design.

Clinical trials-- Statistical methods.

HEALTH & FITNESS-- Holism.

HEALTH & FITNESS-- Reference.

MEDICAL-- Alternative Medicine.

MEDICAL-- Atlases.

MEDICAL-- Essays.

MEDICAL-- Family & General Practice.

MEDICAL-- Holistic Medicine.

MEDICAL-- Osteopathy.

Medicine-- Research-- Methodology.

R (Computer program language)

HEA-- 012000

HEA-- 020000

MBGR1

MED-- 004000

MED-- 029000

MED-- 040000

MED-- 092000

MED-- 101000

MED-- 109000

Number

Edition

Class number

Book number

Class number

Wu, Jianrong

Date of Transaction

20200822113144.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y