Eric J. Nestler, MD, PhD, Nash Family Professor and Chair of Neuroscience, Director, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, Steven E. Hyman, MD, Harvard University Distinguished Service Professor, Professor of Stem Cell and Regenerative Biology, Director, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, David M. Holtzman, MD, Andrew B. and Gretchen P. Jones Professor, Chair, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, Robert C. Malenka, MD, PhD, Pritzker Professor of Psychiatry, Deputy Director, Stanford Neurosciences Institute, Stanford University, Palo Alto, California.
Basic principles of neuropharmacology -- Cellular basis of communication -- Synaptic transmission -- Signal transduction in the brain -- Excitatory and inhibitory amino acids -- Widely projecting systems: monoamines, acetylcholine, and orexin -- Neuropeptides -- Atypical neurotransmitters -- Autonomic nervous system -- Neural and neuroendocrine control of the internal milieu -- Pain -- Neuroinflammation -- Sleep and arousal -- Higher cognitive function and behavioral control -- Mood and emotion -- Reinforcement and addictive disorders -- Schizophrenia and bipolar disorder -- Neurodegeneration -- Seizure disorders -- Stroke and migraine.
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SUMMARY OR ABSTRACT
Text of Note
Reviews the fundamental biochemistry of the functioning nervous system and then describes how nerve cells communicate with one another through numerous types of neurotransmitters involving amino acids, monoamines, neuropeptides, and neurotrophic factors, among several others.