عنوان

Chimerism :

(Number (ISBN

3319898663

(Number (ISBN

9783319898667

Erroneous ISBN

3319898655

Erroneous ISBN

9783319898650

Title Proper

Chimerism :

General Material Designation

[Book]

Other Title Information

a clinical guide /

First Statement of Responsibility

Nicole L. Draper, editor.

Place of Publication, Distribution, etc.

Cham, Switzerland :

Name of Publisher, Distributor, etc.

Springer,

Date of Publication, Distribution, etc.

2018.

Specific Material Designation and Extent of Item

1 online resource (xi, 200 pages) :

Other Physical Details

illustrations (some color)

Text of Note

Includes index.

Text of Note

Intro; Preface; Contents; Contributors; Part I: Causes of Chimerism in Humans; Chapter 1: Fertilization and Early Embryonic Errors; Introduction; Detection of Chimerism; Mechanisms of Abnormal Fertilization; Diandric Chimerism; Androgenetic Chimerism; Digynic Chimerism; Mechanisms of Abnormal Early Embryogenesis; Tetragametic Chimerism; Postzygotic Splitting; Mosaicism; Summary; References; Chapter 2: Pregnancy and Multiple Gestations; Introduction; Chimerism as a Result of Pregnancy; Chimerism as a Result of Multiple Gestations; Persistence of Chimerism.

Text of Note

Clinical Implications of Chimerism in Multiple GestationsSummary; References; Chapter 3: Transplantation and Transfusion; Introduction; Tissue Transplantation; Solid Organ Transplantation; Heart; Kidney; Liver; Lung; Pancreas; Intestine; Hematopoietic Stem Cell Transplantation; Blood Product Transfusion; Transfusion-Associated Microchimerism; Trauma; Combat; HIV; Immunocompetent; Importance of Microchimerism; References; Part II: Clinical Identification and Consequences of Chimerism; Chapter 4: Relationship Testing and Forensics; Introduction; Consequences of Chimerism in Forensics.

Text of Note

Consequences of Chimerism in Relationship TestingCase Study: A Chimeric Father's False Paternity Exclusion; Logic in Testing the Paternity of a Chimeric Alleged Father; Case Conclusions; Case Study: Identifying a Chimeric Child; Case Conclusions; Recommendations for Relationship and Forensic DNA Testing of Undiagnosed Chimera; Limitations to Current DNA Testing Systems; Alternative/Reflexive Testing Recommendations; Future Research; References; Chapter 5: Prenatal Genetic Testing and Screening; Introduction and Definitions; Types of Pregnancy-Related Chimerism.

Text of Note

Fetal Microchimerism and Obstetric or Maternal PathologyNon-chimeric Fetal Cells Accessible for Noninvasive Prenatal Diagnosis; Conclusion; References; Chapter 6: Blood Typing Discrepancies; Introduction; Blood Typing Tests; Red Blood Cell Typing; Secretor Studies; HLA Typing; Molecular Studies; Nature and Investigation of Blood Typing Discrepancies; Clinical Investigation; Laboratory Testing; Molecular Studies; Clinical Cases; Twin Chimerism; Dispermic Chimerism; Tetragametic Chimerism; Feto-maternal Microchimerism; Hematopoietic Transplantation Associated; Transfusion Associated.

Text of Note

Maternal Cells in the Fetus: Maternal Microchimerism (MMC)Fetal Cells in the Mother: Fetal Microchimerism (FMC); Cell-Free Fetal DNA in Maternal Plasma: Transient Acellular Fetal Microchimerism; Pregnancies Resulting from Early Embryonic Chimerism; Chimerism and Mosaicism: Distinct Entities with Different Genetic Diagnostic Implications; Benefits and Pitfalls of Chimerism for Prenatal Genetic Testing; Cell-Based Noninvasive Prenatal Genetic Testing; Chimerism and Cell-Free DNA-Based Testing; Chimerism in Multiple Pregnancies; Monozygotic Twins; Dizygotic Twins.

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Text of Note

This text provides a comprehensive, up-to-date review of chimerism. The first part of the volume presents the causes of chimerism, specifically focusing on fertilization and early embryonic errors, pregnancy and multiple gestations, and transplantation and transfusion. The second part of the volume outlines clinical identification and consequences of chimerism. Chapters in this section focus on the effects of chimerism on testing in relationship determination and forensics, prenatal genetic testing and screening, and blood and HLA typing. This part also reviews new data concerning matching donors and recipients for transplantation, while outlining the risks of transplantation, such as graft-vs-host disease and passenger lymphocyte syndrome. Additionally, evidence on the role of chimerism in autoimmune disease and cancer is presented. Written by experts in the field, Chimerism: A Clinical Guide is a valuable resource for clinicians and researchers that will help guide patient management and stimulate investigative efforts.

Source for Acquisition/Subscription Address

Springer Nature

Stock Number

com.springer.onix.9783319898667

International Standard Book Number

9783319898650

Chimerism.

Chimerism.

Chimerism.

Haematology.

HEALTH & FITNESS-- Diseases-- General.

MEDICAL-- Clinical Medicine.

MEDICAL-- Diseases.

MEDICAL-- Evidence-Based Medicine.

MEDICAL-- Internal Medicine.

HEA-- 039000

MED-- 014000

MED-- 022000

MED-- 045000

MED-- 112000

MJF

Number

Edition

Class number

Draper, Nicole L.

Date of Transaction

20200823114918.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y