Leishmaniasis : the biology of a parasite -- Determinant features in leishmaniasis -- Molecular evolution and phylogeny of leishmania -- The role of reservoirs : cananie leishmaniasis -- Epidemiology of leishmaniasis in the time of drug resistance (the miltefosine era) -- The role of the immune system in resistance to infection -- Challenges in the diagnosis, treatment and control of leishmaniasis in times of drug resistance -- Co-infection with HIV -- Visceral leishmaniasis -- American tegumentary leishmaniasis -- The challenges of effective leishmaniasis treatment -- Molecular features of drug resistant leishmania -- The role of proteomics in the study of drug resistance -- The role of ABC transporters in drug-resistant leishmania -- Functional analysis of leishmania membrane (non-ABC) transporters involved in drug resistance -- Tools and strategies to circumvent drug resistance in leishmania -- Bioinformatics in leishmania drug design -- P-glycoprotein-like transportyers in leishmania : a search for reversal agents -- The concept of fitness in leishmania.
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SUMMARY OR ABSTRACT
Text of Note
Providing a comprehensive review of the epidemiology and pathology of Leishmania and Leishmaniasis, this book offers a close examination of this parasitic disease and its resistance to drugs, including its molecular basis, consequences and possible treatments.