Intro; Preface; Contents; About the Editor; Overview of Leishmaniasis with Special Emphasis on Kala-azar in South Asia; 1 Global Overview of Leishmaniasis; 1.1 Disease Types; 1.2 Disease Incidence/Distribution; 1.3 Transmission; 1.4 Diagnosis; 1.5 Prevention; 1.5.1 Vector Control; 1.5.2 Reservoir Control; 1.5.3 Vaccination; 1.6 Treatment; 1.7 Epidemiology Mathematical Modeling; 1.8 Control Programs; 2 Leishmaniasis in South Asia; 2.1 Clinico-epidemiological Types; 2.2 Indian Kala-azar or visceral leishmaniasis; 2.2.1 Clinical Features
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2.2.2 Splenic Aspiration, Bone Marrow Puncture, and Serodiagnosis2.2.3 Kala-azar Elimination Initiatives; 3 Experimental Leishmaniasis; 3.1 Causative Agents; 3.1.1 Cell/Molecular Biology; 3.1.2 Phylogenetic Taxonomy, Population Genetics, and Evolution; 3.2 Host-Parasite Interactions; 3.2.1 Animal Models; 3.2.2 Vector Models; 3.2.3 Leishmania-Macrophage In Vitro Models; 3.2.4 Future In Vitro and In Vivo Models; 3.3 Leishmania Model for Microbial Virulence; 4 Basic and Applied Kala-azar Research in India; 4.1 Indian Institutions with Kala-azar Research Components; 4.2 Indian Kala-azar Research
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4 Host Immune Responses4.1 Innate Immune Responses; 4.1.1 Inflammasome; 4.2 Adaptive Immunity (Humoral and Cell-Mediated Response); 5 Pathology and Clinical Signs of Amebiasis; 6 Diagnosis; 6.1 Microscopic Examinations; 6.2 Biochemical Method; 6.3 Serological Test; 6.3.1 Antibody Detection; 6.3.2 Antigen Detection Method; 6.4 Molecular Diagnosis; 7 Treatment and Control; 8 Prevention; 9 Conclusions; References; Overview on Ascariasis in Humans in South Asia; 1 Introduction; 1.1 Epidemiology; 1.2 Predisposition; 1.3 Animal Models; 2 Pathogen; 2.1 Types; 2.2 Life Cycle; 3 Clinical Features
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4 Molecular and Biological Aspects4.1 Excretome/Secretome; 4.2 Genome; 5 Ascaris and the Immune System; 5.1 Immune Response; 5.2 Immunoglobulins; 5.3 Th2 Response; 5.4 Regulations of the Immune System; 5.5 Other Proteins Involved; 5.6 Natural Immunity; 6 Diagnosis and Treatment; 6.1 Diagnosis; 6.2 Treatment; 7 Coinfections and Allergies; 7.1 Ascaris Coinfection; 7.1.1 Ascaris and HIV; 7.1.2 Ascaris and Malaria; 7.2 Allergies and Ascaris; 8 Prevention and Control; 9 Conclusion; References; Overview of Hookworm Infection in Humans; 1 Soil-Transmitted Helminths: Introduction; 2 Pathogens
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5 Concluding Remarks5.1 ``Leishmaniome ́́and Diversity of Leishmaniasis; 5.2 Issues Emerged from South Asia Kala-azar Elimination Initiatives; 5.3 Indian Leadership in One-Health Approach to Research Collaboration; 6 List of Collaborators; Appendix; References; Human Amebiasis: Insight into the Biology and Immunopathogenesis; 1 Introduction; 2 Entamoeba histolytica Biology; 3 Pathogenesis of E. histolytica; 3.1 E. histolytica Colonization and Exposure to Intestinal Environment; 3.2 E. histolytica Invasion; 3.2.1 Gal/GalNAc Lectin; 3.3 Cysteine Proteases; 3.4 Amebapores; 3.5 Phagocytosis