عنوان
پدید آورنده
موضوع
رده
QP143.5.M37 M3 2019eb
QP143
.
5
.
M37
M3
2019eb
کتابخانه
محل استقرار
INTERNATIONAL STANDARD BOOK NUMBER
(Number (ISBN
3319399926
(Number (ISBN
3319399934
(Number (ISBN
3319399942
(Number (ISBN
9783319399928
(Number (ISBN
9783319399935
(Number (ISBN
9783319399942
Erroneous ISBN
9783319399928
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Computer modelling for nutritionists /
General Material Designation
[Book]
First Statement of Responsibility
Mark Tomás Mc Auley.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Cham :
Name of Publisher, Distributor, etc.
Springer,
Date of Publication, Distribution, etc.
[2019]
Date of Publication, Distribution, etc.
©2019
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
1 online resource
INTERNAL BIBLIOGRAPHIES/INDEXES NOTE
Text of Note
Includes bibliographical references and index.
CONTENTS NOTE
Text of Note
Intro; Preface; Acknowledgements; Contents; About the Author; 1 Introduction; 1.1 Introduction: The Systems Biology Paradigm Shift; 1.2 What Is Computational Modelling?; 1.3 Why Nutrition Needs Modelling; 1.4 Computer Models and Nutrition Research; 1.4.1 Folate Metabolism; 1.4.2 Models of Folate Metabolism; 1.4.3 Cholesterol Metabolism; 1.4.4 Models of Cholesterol Metabolism; 1.5 Can Modelling Unravel the Relationship Between Diet and Healthspan?; 1.6 Exercises; References; 2 Kinetics; 2.1 What Is Kinetics?; 2.2 Deterministic Kinetics and the Law of Mass Action; 2.3 Zero Order Reactions
Text of Note
2.4 First Order Reactions2.5 Second Order Rate Laws; 2.6 Exercises; References; 3 Enzyme Kinetics; 3.1 Introduction; 3.1.1 Michaelis-Menten Kinetics; 3.1.2 Michaelis Menten (Reversible); 3.2 Enzyme Inhibition; 3.3 The Hill Equation; 3.4 Exercises; References; 4 Model Building: Part One; 4.1 The Steps in Building a Kinetic Model; 4.2 Step One: Identifying a System to Model and Defining a Hypothesis; 4.3 Step Two: Listing the Variables and How They Interact; 4.4 Step Three: Creating a Network Diagram; 4.5 Step Four: Identifying and Using a Software Tool
Text of Note
4.6 Step Five: Adding Biochemical Reactions4.6.1 Adding a Rate Law Which Does Not Exist in COPASI/CellDesigner; 4.7 Exercises; References; 5 Model Building: Part Two; 5.1 Introduction; 5.2 Step Six: Model Parameterization; 5.3 Step Seven: Model Simulation; 5.4 Step Eight: Validation and Hypothesis Exploration; 5.5 Step Ten: Model Archiving; 5.6 Exercises; References; 6 Model Analysis in Greater Depth; 6.1 Steady State Analysis; 6.2 Phase Space Analysis; 6.3 Parameter Perturbations and Bifurcations; 6.4 The Brusselator and Limit Cycles; 6.5 Identifying the Stability of Larger Models
Text of Note
6.5.1 Identifying Model Stability Using COPASI6.6 Performing a Local Parameter Scan; 6.7 Metabolic Control Analysis; 6.8 Performing a Sensitivity Analysis; 6.9 Exercises; References; 7 Investigating Cholesterol Metabolism and Its Intersection with Ageing; 7.1 Cholesterol Metabolism: Some Mechanistic Detail; 7.2 Cholesterol Absorption and Ageing; 7.3 Hepatic LDLr and Ageing; 7.4 Cholesterol Biosynthesis; 7.5 Exercises; References; 8 Modelling Folate Metabolism and DNA Methylation; 8.1 Introduction; 8.2 Explore Folate Metabolism and Health; 8.3 Computationally Modelling DNA Methylation
Text of Note
8.4 Stochastic Modelling DNA Methylation8.5 Rationale for Modelling DNA Methylation Using a Stochastic Framework; 8.6 Exercises; References; Index
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8
8
8
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SUMMARY OR ABSTRACT
Text of Note
This book draws on Mark Mc Auley's wealth of experience to provide an intuitive step-by-step guide to the modelling process. It also provides case studies detailing the creation of biological process models. Mark Mc Auley has over 15 years' experience of applying computing to challenges in bioscience. Currently he is employed as a Senior Lecturer in Chemical Engineering at the University of Chester. He has published widely on the use of computer modelling in nutrition and uses computer modelling to both enhance and enrich the learning experience of the students that he teaches. He has taught computer modelling to individuals at a wide variety of levels and from different backgrounds, from undergraduate nutrition students to PhD and medical students.
ACQUISITION INFORMATION NOTE
Source for Acquisition/Subscription Address
Springer Nature
Stock Number
com.springer.onix.9783319399942
OTHER EDITION IN ANOTHER MEDIUM
International Standard Book Number
9783319399928
International Standard Book Number
9783319399935
TOPICAL NAME USED AS SUBJECT
Nutrition-- Computer simulation.
Nutrition-- Mathematical models.
Nutrition-- Mathematical models.
(SUBJECT CATEGORY (Provisional
PSB
PSB
SCI007000
DEWEY DECIMAL CLASSIFICATION
Number
572/
.
4072
Edition
23
LIBRARY OF CONGRESS CLASSIFICATION
Class number
QP143
.
5
.
M37
Book number
M3
2019eb
PERSONAL NAME - PRIMARY RESPONSIBILITY
Mc Auley, Mark Tomás
ORIGINATING SOURCE
Date of Transaction
20200823101544.0
Cataloguing Rules (Descriptive Conventions))
pn
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب [Book]
Y
