عنوان

Surface enhanced raman spectroscopy for biophysical applications :

(Number (ISBN

3030035565

(Number (ISBN

9783030035563

Erroneous ISBN

3030035557

Erroneous ISBN

9783030035556

Title Proper

Surface enhanced raman spectroscopy for biophysical applications :

General Material Designation

[Book]

Other Title Information

using plasmonic nanoparticle assemblies /

First Statement of Responsibility

Claudia Fasolato.

Place of Publication, Distribution, etc.

Cham, Switzerland :

Name of Publisher, Distributor, etc.

Springer,

Date of Publication, Distribution, etc.

2018.

Specific Material Designation and Extent of Item

1 online resource (xviii, 155 pages) :

Other Physical Details

illustrations (some color)

Series Title

Springer theses,

ISSN of Series

2190-5053

Text of Note

"Doctoral thesis accepted by the Sapienze University of Rome, Rome, Italy."

Text of Note

Intro; Supervisor's Foreword; Abstract; Parts of this thesis have been published in the following articles; Acknowledgements; Contents; 1 Introduction; References; 2 Traditional Raman and SERS: Fundamentals and State of the Art; 2.1 Optical Vibrational Spectroscopy of Molecules; 2.1.1 Theory of Raman Scattering; 2.2 Surface Enhanced Raman Scattering; 2.2.1 Electromagnetic Mechanism; 2.2.2 Chemical Mechanism; 2.3 Current Trends in Surface Enhanced Raman Scattering; 2.3.1 Nanoparticle-Based SERS Substrates; 2.3.2 SERS Applications in Nanomedicine

Text of Note

2.3.3 Non Metallic Substrates: SERS from Semiconductor NanostructuresReferences; 3 Investigation on Nanoparticles and Their Molecular Functionalization; 3.1 Model Functionalization with 4ATP Linker; 3.1.1 Preparation and Control Characterization; 3.1.2 SERS Versus Raman Spectrum; 3.2 Further Conjugation: Folate and Antifolates; 3.2.1 Nanovector Functionalization: The Case of Folate; 3.2.2 SERS Signature of Folate/Antifolate Nanovectors; 3.3 Experimental Details; References; 4 Nanoparticle-Based SERS Substrates for Molecular Sensing Applications

Text of Note

4.1 Self-assembled Mesoscopic Silver Nanoparticle Clusters4.1.1 Coupled AFM and Raman Analysis; 4.1.2 Dimensional Scale Effect on SERS Efficiency; 4.2 FDTD Simulation: Theoretical Predictions; 4.2.1 The FDTD Software; 4.2.2 Results on Silver and Gold Np Multilayers; 4.3 Electron Beam Lithography Driven Self-assembly; 4.3.1 Nanoparticle Cluster Array Preparation; 4.3.2 Analysis of the Patterned Arrays; 4.3.3 Analysis of the Ordered Nanoparticle Cluster Arrays; 4.3.4 SERS Reproducibility; References; 5 SERS-Active Nanovectors for Single-Cell Cancer Screening and Theranostics

Text of Note

5.1 Early Cancer Diagnostics and Theranostics5.2 Folate-Based SERS Diagnostics; 5.2.1 Idea of the Experiment; 5.2.2 Cell Treatment and Viability Tests; 5.2.3 Raman and SERS Imaging on Treated Cells; 5.2.4 SEM Imaging on Treated Cells; 5.2.5 SERS Screening and Results; 5.3 From Selectivity to Theranostics: Antifolate Nanovectors; 5.3.1 Preliminary Cytotoxicity Results; 5.3.2 Enhanced Toxicity of Nanostructured Drugs; References; 6 Conclusions; A SERS Application in Cultural Heritage; A.1 HPTLC-SERS Investigation of Madder Lake Ammonia Extract; A.1.1 HPTLC-SERS Analytical Method

Text of Note

A.1.2 Experimental ResultsA. 2 A Multianalytical Study Unravels Purple Dyeing Processes: The Case of a Historical Dress from the 19th Century; A.2.1 Introduction; A.2.2 Sicilian Noblewoman Dress: Microscopy, Sampling, Experimental Details; A.2.3 Results and Discussion; A.2.4 Conclusions; Curriculum Vitae

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Text of Note

The book explores the phenomenon of surface-enhanced Raman scattering (SERS), the huge amplification of Raman signal from molecules in the proximity of a metallic nanostructured surface, allowing readers to gain an in-depth understanding of the mechanisms affecting the spectroscopic response of SERS-active systems for effective applications. SERS spectroscopy is an ultrasensitive analytical technique with great potential for applications in the field of biophysics and nanomedicine. As examples, the author presents the design of nanocolloid-based SERS-active substrates for molecular sensing and of a folate-based SERS-active nanosensor capable of selectively interacting with cancer cells, enabling cancer diagnostics and therapy at the single-cell level. The author also suggests novel paths for the systematization of the SERS nanosystem design and experimental protocols to maximize sensitivity and reproducibility, which is essential when real-world biomedical applications are the goal of the study. With a combined approach, both fundamental and applied, and a detailed analysis of the state of the art, this book provides a valuable overview both for students new to SERS spectroscopy and for experts in the field.

Source for Acquisition/Subscription Address

Springer Nature

Stock Number

com.springer.onix.9783030035563

International Standard Book Number

9783030035556

International Standard Book Number

9783030035570

Raman effect, Surface enhanced.

Raman spectroscopy.

Raman effect, Surface enhanced.

Raman spectroscopy.

PDN

PNFS

PNFS

SCI078000

Number

Edition

Class number

Fasolato, Claudia

Date of Transaction

20200823075542.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y