Natural products as source of molecules with therapeutic potential :
General Material Designation
[Book]
Other Title Information
research & development, challenges and perspectives /
First Statement of Responsibility
editor, Valdir Cechinel Filho.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Cham, Switzerland :
Name of Publisher, Distributor, etc.
Springer,
Date of Publication, Distribution, etc.
[2018]
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
1 online resource
GENERAL NOTES
Text of Note
Includes index.
CONTENTS NOTE
Text of Note
Intro; Dedication; Acknowledgments; Contents; About the Editor; Medicinal Plants and Phytomedicines; 1 Introduction; 2 Quality Control of Phytomedicines; 2.1 Quality and Efficacy of Plant Material; 2.2 Production Methods; 3 Medicinal Teas Today; 4 Modern Phytotherapy; 4.1 New Scientific Screening; 4.2 Mechanism of Action; 4.3 Synergy; 5 Some Selected Phytomedicines; 5.1 Ginkgo biloba (Ginkgo); 5.2 Serenoa repens (Saw Palmetto); 5.3 Valeriana officinalis (Valerian); 5.4 Hypericum perforatum (St. John's Wort); 5.5 Allium sativum (Garlic); 5.6 Piper methysticum; 5.7 Glycine max (Soy)
Text of Note
3.2 Kefir3.3 Kombucha; 4 Prebiotics; 5 Synbiotics; 6 Conclusions; References; The Role of Flavonoids as Modulators of Inflammation and on Cell Signaling Pathways; 1 Introduction; 2 Absorption and Metabolism of Flavonoids; 3 Inflammation; 3.1 Inflammatory Mediators; 3.1.1 Nitric Oxide; 3.1.2 Arachidonic Acid Metabolites; 3.1.3 Cytokines; 3.1.4 Chemokines; 3.1.5 Cell Adhesion Molecules; 3.2 Inflammation-Associated Intracellular Signaling Pathways; 3.2.1 Nuclear Transcription Factor Kappa-B (NF-kB) Pathway; 3.2.2 Signal Transducer and Activator of Transcription (STAT) Protein Family
Text of Note
4 Production of Antimicrobials Through Plant Tissue Cultures4.1 Production of Antimicrobials Through Plant Cell Cultures; 4.2 Production of Antimicrobials Through Plant Organ Cultures; 4.3 Production of Antimicrobials Through Plantlets Propagated In Vitro; 5 Conclusions; References; Liquid Chromatography for Plant Metabolite Profiling in the Field of Drug Discovery; 1 Introduction; 2 Sample Preparation; 3 Development of the Metabolite Profile; 3.1 Thin-Layer Chromatography; 3.2 Column Chromatography; 3.3 Detectors; 3.3.1 Spectroscopic Detection; 3.3.2 Mass Spectrometric Detection; Ionization
Text of Note
5.8 Matricaria chamomilla5.9 Maytenus ilicifolia; 5.10 Ilex paraguariensis; 5.11 Cynara scolymus L.; 5.12 Phyllanthus niruri; 6 Case Study: Development of the Phytomedicine from Biodiversity; 7 Conclusions; References; Plant Products with Antifungal Activity: From Field to Biotechnology Strategies; 1 Introduction; 2 Human Fungal Diseases; 3 Antifungal Susceptibility Methods; 3.1 Anti-Candida Plant Products; 3.2 Anti-dermatophytes Plant Products; 3.3 Anti-Malassezia Plant Products; 3.4 Anti-Aspergillus Plant Products; 3.5 Anti-Cryptococcus Plant Products
Text of Note
Mass AnalysisFragmentation; From MS Spectra to Compound Identification; 4 Pharmacological Evaluation; 5 Multivariate Data Handling of Chromatographic Fingerprints; 6 Applications of Metabolite Profile; 6.1 Linked to In Vitro Reaction Assays; 6.2 Linked to In Vitro Enzymatic Assays; 6.3 Linked to In Vivo Assays; 7 Conclusions; References; Functional Foods as Source of Bioactive Principles: Some Marked Examples; 1 Introduction; 2 Functional Foods; 2.1 Curcuma; 2.2 Garlic; 2.3 Omega-3; 2.4 Olive Oil; 2.5 Tea; 2.6 Ginger; 2.7 Broccoli; 2.8 Grape; 2.9 Black Pepper; 3 Probiotics; 3.1 Yogurt
0
8
8
8
8
SUMMARY OR ABSTRACT
Text of Note
This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.