3.2.1 Polymers with Ionizable Functional Groups3.2.1.1 pH-responsive Acidic Polymers; 3.2.1.2 pH-responsive Basic Polymers; 3.2.1.3 pH-responsive Natural Polymers; 3.2.2 Acid-labile pH-sensitive Nanocarriers; 3.2.3 pH-responsive Inorganic Nanoscale Materials; 3.3 Release Mechanism of pH-responsive DDS; 3.3.1 Hydrophobic-Hydrophilic Transition Induced Disassembly; 3.3.2 Cleavage of Acid-labile Linkers for Drug Release; 3.3.3 Gel Swelling; 3.3.4 Cap/Coating Removal; 3.3.5 Gas Generation; 3.4 pH-responsive DDS for Targeted Delivery; 3.4.1 PEG Shedding; 3.4.2 Ligand Shielding/Deshielding
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3.4.3 Ligand Pop-up Targeting3.4.4 Charge Reversal; 3.4.5 Size Change; 3.4.6 Membrane Fusion by pH-sensitive Peptides; 3.4.6.1 pH-(Low) Insertion Peptide (pHLIP); 3.4.6.2 pH-activatable Cell-penetrating Peptides CPPs; 3.5 pH-responsive DDS for Intracellular Delivery; 3.6 Conclusions; References; Chapter 4 -- Thermo-responsive Nanomedicines for Drug Delivery in the Gastrointestinal Tract; 4.1 Introduction; 4.2 Gastrointestinal Tract; 4.2.1 Constitution of the Gastrointestinal Tract; 4.2.2 Differences Between Normal and Diseased Tissues; 4.2.3 Inflammatory Bowel Disease
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4.2.4 Gastric and Colorectal Cancer4.3 Thermo-responsive Materials and Nanocarrier Systems; 4.3.1 Thermo-responsive Polymeric Nanoparticles; 4.3.2 Thermo-responsive Liposomes; 4.3.3 Thermo-responsive Micelles; 4.4 Conclusions and Future Perspectives; Acknowledgements; References; Chapter 5 -- Redox-responsive Drug Delivery Systems; 5.1 Redox-responsive Drug Delivery Systems; 5.1.1 Redox Profile of the Tumor Microenvironment and the Cancer Cell; 5.1.1.1 Reactive Oxygen Species; 5.1.1.2 Glutathione; 5.1.1.3 Redox Potential in Cancer Cell; 5.1.2 Reduction (Glutathione)-responsive Systems
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SUMMARY OR ABSTRACT
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This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials.