عنوان
پدید آورنده
موضوع
رده
RB155.8
RB155
.
8
کتابخانه
محل استقرار
INTERNATIONAL STANDARD BOOK NUMBER
(Number (ISBN
1788012925
(Number (ISBN
1788014286
(Number (ISBN
9781788012928
(Number (ISBN
9781788014281
Erroneous ISBN
1782629920
Erroneous ISBN
9781782629924
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
DNA-targeting molecules as therapeutic agents /
General Material Designation
[Book]
First Statement of Responsibility
editor: Michael J. Waring.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Cambridge :
Name of Publisher, Distributor, etc.
Royal Society of Chemistry,
Date of Publication, Distribution, etc.
2018.
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
1 online resource (414 pages)
SERIES
Series Title
Chemical biology ;
Volume Designation
7
GENERAL NOTES
Text of Note
Includes index.
INTERNAL BIBLIOGRAPHIES/INDEXES NOTE
Text of Note
Includes bibliographical references and index.
CONTENTS NOTE
Text of Note
Cover; Preface to Sequence-specific DNA Binding Agents; Preface; Contents; Chapter 1 DNA Recognition by Parallel Triplex Formation; 1.1 Why Triplexes?; 1.1.1 Triplets and Triplex Motifs; 1.1.2 Base, Sugar and/or Phosphate Modifications; 1.2 Stabilising Triplexes; 1.2.1 Enhancing Stacking and Hydrophobic Interactions; 1.2.2 Locking the Sugar Pucker; 1.2.3 Adding Positive Charge(s); 1.2.4 Removing Negative Charge(s); 1.2.5 Triplex-binding and Cross-linking Agents; 1.3 Decreasing pH Dependence; 1.3.1 Pyrimidine Analogues; 1.3.2 Purine Analogues; 1.4 Recognising Pyrimidine-Purine Base Pairs
Text of Note
1.4.1 Null Bases and Abasic Linkers1.4.2 Natural Bases; 1.4.3 Analogues for CG Recognition; 1.4.4 Analogues for TA Recognition; 1.4.5 Other Approaches; 1.5 Towards Mixed Sequence Recognition at Neutral pH; 1.6 Outlook; Acknowledgements; References; Chapter 2 Interfacial Inhibitors; 2.1 Introduction; 2.2 Case Studies; 2.2.1 Topoisomerase Inhibitors; 2.2.2 HIV Integrase Strand Transfer Inhibitors; 2.2.3 STING Inhibitors; 2.2.4 Arp2-3 Inhibitors; 2.3 Prospects; Acknowledgements; References; Chapter 3 Slow DNA Binding; 3.1 Introduction-Kinetics vs. Thermodynamics of DNA Binding
Text of Note
4.2.1 Analysis of Tm shifts in the Presence of Drug4.2.2 Obtaining Binding Enthalpy Values by DSC; 4.2.3 Modeling Melting Curves by McGhee's Algorithm; 4.2.4 Case Studies: Bisintercalating Anthracyclines and Echinomycin; 4.2.5 Summary: Advantages and Pitfalls; 4.3 High-throughput Thermal Denaturation Approaches; 4.3.1 Differential Scanning Fluorimetry; 4.3.2 DSC Compared with DSF: Slow and Expensive but Definitive; 4.3.3 Illustrations of Differential Scanning Fluorimetry Data and Utility; 4.3.4 Advantages and Prospects; 4.4 Summary; Acknowledgements; References
Text of Note
Chapter 5 Computer Simulations of Drug-DNA Interactions: A Personal Journey5.1 Introduction; 5.2 Minor Groove DNA Binders; 5.3 Natural Bifunctional Intercalators and Hoogsteen Base Pairing; 5.4 Bis-intercalation of Echinomycin and Related Bifunctional Agents in Relation to Binding Sequence Preferences; 5.5 Binding Preferences of Synthetic Pyridocarbazole Bis-intercalators; 5.6 Sequence Selectivity of Actinomycin D; 5.7 Binding of the Potent Antitumor Agent Trabectedin to DNA; 5.8 Other Examples of DNA Minor-groove-bonding Tetrahydroisoquinoline Antibiotics; 5.9 Melting DNA on the Computer
0
8
8
8
SUMMARY OR ABSTRACT
Text of Note
This book explains key aspects of the progress that has been made towards understanding how drugs can bind specifically to nucleic acids, and thus underpin the endeavour to make gene targeting a reality. The binding of drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents and treats in depth topics such as DNA-binding metal complexes, peptide and polyamide-DNA interactions.
ACQUISITION INFORMATION NOTE
Source for Acquisition/Subscription Address
Royal Society of Chemistry
Stock Number
5052:4904
OTHER EDITION IN ANOTHER MEDIUM
Title
DNA-targeting molecules as therapeutic agents.
Title
DNA-targeting molecules as therapeutic agents.
International Standard Book Number
1782629920
International Standard Book Number
9781788012928
TOPICAL NAME USED AS SUBJECT
DNA-drug interactions.
Gene therapy.
DNA-- drug effects.
Gene Targeting-- methods.
Molecular Targeted Therapy-- methods.
DNA-drug interactions.
Gene therapy.
MEDICAL-- Pharmacology.
(SUBJECT CATEGORY (Provisional
MED-- 071000
DEWEY DECIMAL CLASSIFICATION
Number
615
.
8/95
Edition
23
LIBRARY OF CONGRESS CLASSIFICATION
Class number
RB155
.
8
OTHER CLASS NUMBERS
Class number
QU
560
PERSONAL NAME - ALTERNATIVE RESPONSIBILITY
Waring, Michael J.
ORIGINATING SOURCE
Date of Transaction
20200823053619.0
Cataloguing Rules (Descriptive Conventions))
pn
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب [Book]
Y
