عنوان
پدید آورنده
موضوع
رده
QD262 .C44 2018eb
QD262
.
C44
2018eb
کتابخانه
محل استقرار
INTERNATIONAL STANDARD BOOK NUMBER
(Number (ISBN
1788012801
(Number (ISBN
9781788012805
Erroneous ISBN
1782629483
Erroneous ISBN
9781782629481
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Chemical and biological synthesis :
General Material Designation
[Book]
Other Title Information
enabling approaches for understanding biology /
First Statement of Responsibility
editors: Nick J. Westwood, Adam Nelson.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Cambridge :
Name of Publisher, Distributor, etc.
Royal Society of Chemistry,
Date of Publication, Distribution, etc.
2018.
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
1 online resource (xii, 404 pages) :
Other Physical Details
illustrations
SERIES
Series Title
Chemical biology ;
Volume Designation
10
GENERAL NOTES
Text of Note
Includes index.
Text of Note
Title from title details screen.
INTERNAL BIBLIOGRAPHIES/INDEXES NOTE
Text of Note
Includes bibliographical references and index.
CONTENTS NOTE
Text of Note
Cover; Contents; Section 1: Synthetic Approaches to Enable Small-molecule Probe Discovery; Chapter 1 Synthetic Tools for the Elucidation of Biological Mechanisms; 1.1 Context; 1.2 Synthetic Approaches to Enable Small-molecule Probe Discovery; 1.3 Synthetic Approaches to Classes of Modified Biomolecule; 1.4 Summary; References; Chapter 2 The Application of Diversity-oriented Synthesis in Chemical Biology; 2.1 Introduction; 2.1.1 Small Molecule Screening Collections; 2.1.2 Sources of Complex and Diverse Libraries
Text of Note
2.1.3 Synthetic Strategies for the Construction of Complex and Diverse Libraries: Diversity-oriented Synthesis2.2 Application of Diversity-oriented Synthesis for the Identification of Small Molecule Modulators; 2.2.1 Structural Diversity and Phenotypic Screening; 2.2.2 The Role of DOS in Target Validationthrough the Discovery of New Chemical Probes; 2.3 Conclusions and Outlook; Acknowledgements; References; Chapter 3 Biology-oriented Synthesis; 3.1 Introduction; 3.2 Structural Classification of Natural Products, Protein Structure Similarity Clustering and Scaffold Hunter
Text of Note
3.3 Implications and Opportunities for Biology-oriented Synthesis3.4 Applications of Biology-oriented Synthesis; 3.4.1 Chemical-structure-and Bioactivity-guided Approaches; 3.4.2 Protein-structure-clustering-guided Approaches; 3.4.3 Natural-product-derived-fragment-based Approaches; 3.5 Conclusions and Outlook; References; Chapter 4 Lead- and Fragment-oriented Synthesis; 4.1 Introduction; 4.1.1 Introduction to Lead-oriented Synthesis; 4.1.2 Introduction to Fragment-oriented Synthesis; 4.2 Lead-oriented Synthesis; 4.2.1 Diverse and Novel Scaffolds for Lead-oriented Synthesis
Text of Note
4.2.2 New Synthetic Methods for Lead-oriented Synthesis4.2.3 Natural Products as Inspiration for Lead-like Libraries; 4.2.4 The European Lead Factory; 4.3 Fragment-oriented Synthesis; 4.4 Conclusions; References; Chapter 5 Principles and Applications of Fragment-based Drug Discovery for Chemical Probes; 5.1 Introduction; 5.1.1 What Is a Chemical Probe?; 5.1.2 Chemical Probe Characteristics; 5.1.3 Fragment Library Design; 5.1.4 Screening Methods/Fragment Elaboration; 5.2 Case Studies; 5.2.1 A-1155463 (BCL-XL); 5.2.2 CCT244747 (CHK1); 5.2.3 GSK2334470 (PDK1); 5.2.4 PFI-3 (SMARCA2/4 and PB1)
Text of Note
5.2.5 BI-9564 (BRD9)5.2.6 Astex DDR1 Kinase Inhibitor (DDR1/DDR2); 5.3 Outlook; Abbreviations; References; Chapter 6 Function-driven Discovery of Bioactive Small Molecules; 6.1 Context; 6.1.1 Chemical Approaches That Underpin Bioactive Small-molecule Discovery; 6.1.2 Evolution of Biosynthetic Pathways to Natural Products; 6.1.3 Scope of This Chapter; 6.2 Synthetic Fermentation; 6.2.1 Discovery of a Protease Inhibitor; 6.2.2 Conclusion; 6.3 Activity-directed Synthesis; 6.3.1 Discovery of Androgen Receptor Agonists Using Intramolecular Reactions
0
8
8
8
8
SUMMARY OR ABSTRACT
Text of Note
An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.
ACQUISITION INFORMATION NOTE
Source for Acquisition/Subscription Address
Royal Society of Chemistry
Stock Number
5041:4893
OTHER EDITION IN ANOTHER MEDIUM
Title
Chemical and biological synthesis.
International Standard Book Number
9781782629481
TOPICAL NAME USED AS SUBJECT
Biosynthesis.
Organic compounds-- Synthesis.
Organic Chemicals-- chemical synthesis.
Synthetic Biology.
Biosynthesis.
Organic compounds-- Synthesis.
SCIENCE-- Chemistry-- Organic.
(SUBJECT CATEGORY (Provisional
SCI-- 013040
DEWEY DECIMAL CLASSIFICATION
Number
547/
.
2
Edition
23
LIBRARY OF CONGRESS CLASSIFICATION
Class number
QD262
Book number
.
C44
2018eb
OTHER CLASS NUMBERS
Class number
2019
F-438
Class number
QD
262
PERSONAL NAME - ALTERNATIVE RESPONSIBILITY
Nelson, Adam
Westwood, Nick J.
ORIGINATING SOURCE
Date of Transaction
20200823053607.0
Cataloguing Rules (Descriptive Conventions))
pn
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب [Book]
Y
