عنوان

Pvp

(Number (ISBN

0873712889

(Number (ISBN

1351420836

(Number (ISBN

9780873712880

(Number (ISBN

9781351420839

Erroneous ISBN

9780873712880

Title Proper

Pvp

General Material Designation

[Book]

Other Title Information

A Critical Review of the Kinetics and Toxicology of Polyvinylpyrrolidone (Povidone)

Place of Publication, Distribution, etc.

Boca Raton

Name of Publisher, Distributor, etc.

Routledge

Date of Publication, Distribution, etc.

2018

Specific Material Designation and Extent of Item

1 Online-Ressource (232 Seiten)

Text of Note

1. Absorption of PVP -- A. Rat studies -- B. Other studies -- 2. Renal Elimination of PVP -- A. Animal studies-rat -- B. Animal studies-other species -- C. Human studies-healthy subjects -- D. Human studies-patients -- 3. Distribution of PV P -- A. Pharmacokinetic studies -- B. Tissue uptake studies -- C. Histological studies -- D. Intravenous administration to humans -- E. Mechanism of uptake -- 4. Acute Toxicity of PVP -- 5. Subchronic Toxicity of PVP -- A. Rat studies -- B. Cat and dog studies -- 6. Chronic Toxicity of PVP -- A. Rat studies -- B. Dog studies -- 7. Teratogenicity of PV P -- 8. Mutagenicity of PV P -- A. In vitro studies -- B. In vivo studies -- 9. Carcinogenicity of PVP -- A. Hueper studies -- B. Rat studies-oral route -- C. Rat studies-other routes -- D. Other species -- Index

Text of Note

Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- 1: Introduction -- Pharmaceutical Use -- Foods and Beverages -- Cosmetics and Toiletries -- Photographic Products -- Dyeing Applications and Inks -- Detergents -- Suspensions, Dispersions, and Emulsions -- Production of Plastics -- Adhesives -- Paints and Coatings -- Paper Auxiliaries -- Tabletting Auxiliéiry -- Other Industrial Uses -- 2: Synthesis and Properties of PVP -- Synthesis of PVP -- Nomenclature -- Soluble polymers -- Insoluble polymers -- Classification of PVP Polymers -- Different Methods of Assessing the Molecular Weight -- Distribution of Molecular Weights Within a Given PVP Product -- Physical and Chemical Properties -- Physical -- Chemical -- Specifications -- Presence of Contaminants in Commercially Available PVP -- Monomer -- 2-Pyrrolidone -- Hydrazine -- Acetaldehyde -- 3: Movement of Large Molecules Across Membranes-General Considerations -- Introduction -- Physicochemical Factors -- Movement of PVP Across Membranes -- Glomerular transport of PVP -- 4: Absorption of PVP by Various Routes of Administration -- Introduction -- Oral Administration -- Evidence of Absorption from Toxicity Studies -- Absorption Studies Using Chemical Analysis of PVP -- Absorption Studies Using Radio-Labelled PVP -- General problems -- Studies using radio-iodine (131I and 125I) -- Studies using radio-carbon ('14C) -- Absorption Studies Using Iodine-Labelled PVP -- Absorption Studies Using 14C-Labelled PVP -- Absorption Studies of PVP in Humans -- Discussion of Studies of Oral Absorption of PVP -- Summary of Main Findings -- Conclusions -- Intramuscular and Subcutaneous Administration of PVP -- Summary of Main Findings -- Absorption of PVP by Inhalation -- 5: Excretion and Metabolism of PVP -- Introduction -- Animal Studies -- Human Studies -- Discussion

Text of Note

Of Main Findings -- Metabolism of PVP -- Biliary Excretion -- Summary of Main Findings -- 6: Distribution and Storage of PVP -- Introduction -- Pharmacokinetic Studies of PVP -- Distribution Studies of PVP -- Distribution of PVP as Measured in Histopathological and Toxicity Studies -- Summary of Main Findings -- 7: Storage of PVP in Humans -- Storage of PVP in Humans Following Intravenous Administration -- Storage of PVP in Humans Following Intramuscular or Subcutaneous Administration ("Dupont-Lachapelle Disease") -- Factors to be Considered in the Use of Polymers in Injectable Preparations -- Studies of the Effects of Inhaled PVP -- Discussion Concerning the Distribution and Storage of PVP in Tissues -- Summary of Main Findings -- 8: Functional Consequences of PVP Uptake by Body Tissues, with Particular Reference to the Reticuloendothelial System (RES) and the Immune System -- Mechanism of Uptake of PVP into Body Tissues -- General considerations -- Studies on the Mechanisms of PVP Uptake -- Functional Consequences of PVP Uptake into Body Tissues -- Effect of PVP on the RES -- PVP Shock Reactions -- Immunological Effects of PVP -- Summary of Main Findings -- 9: Toxicological Studies on PVP -- Acute Toxicity -- Subchronic Toxicity -- Parenteral Studies -- Local tissue tolerance -- Chronic Toxicity Studies -- Reproductive Toxicity Studies -- Mutagenicity Studies -- In vitro tests -- In vivo tests -- Carcinogenicity Studies -- Oral studies -- Parenteral studies -- Hueper Studies on PVP -- Discussion of the Parenteral Carcinogenicity Studies -- Anticarcinogenic Activity of PVP -- Summary of Main Findings -- 10: Overall Summary and Conclusions -- Chemistry and Uses -- Biological Activity -- Absorption -- Distribution, Storage, and Excretion -- Metabolism -- Pharmacological Effects -- Toxicology and Safety -- References -- Appendix

Title

Pvp : A Critical Review of the Kinetics and Toxicology of Polyvinylpyrrolidone (Povidone).

International Standard Book Number

9780873712880

Number

Class number

Schwarz, Wolfgang

Borzelleca, J. F.

Schwartz, S. L.

Sullivan, F. M.

Date of Transaction

20200822142942.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y