David Chambers, BMBCh, MChem, DPhil, MRCP, FRCA, PGDipMedEd, Speciality Registar, Salford Royal NHS Foundation Trust, North West School of Anaesthesia, Manchester, UK, Christopher Huang, BMBCh, PhD, DM, DSc, FSB, Professor of Cell Phisiology and Fellow Director of Medical Studies, Murray Edwards College, University of Cambridge, UK, Gareth Matthews, MA, PhD, MSB, Translational Medicine and Theraputics Research Fellow, School of Clinical Medicine and Fellow in Medical Physiology, Murray Edwards College, University of Cambridge, UK.