عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
NATIONAL BIBLIOGRAPHY NUMBER
Number
TLets760520
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Analysis of emerging environmental contaminations using advanced instrumental tools :
General Material Designation
[Thesis]
First Statement of Responsibility
Nguyen, Khanh Hoang
Title Proper by Another Author
application to human and environmental exposure
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
University of Birmingham
Date of Publication, Distribution, etc.
2018
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
Thesis (Ph.D.)
Text preceding or following the note
2018
SUMMARY OR ABSTRACT
Text of Note
High throughput analytical methods based on UPLC-APCI-HRMS and/or UPLC-ESI-HRMS were developed for the multi-residue analysis of pharmaceuticals, personal care products (PPCPs), brominated flame retardants (BFRs) and their degradation/transformation products. The PPCPs method was successfully applied to analysis of freshwater samples from Egypt. Target PPCPs were ubiquitous in the Egyptian aquatic environment and displayed relatively high concentrations in an effluent sample from a hospital wastewater treatment plant. The BFRs method was applied to screen for legacy BFRs, novel BFRs and their potential degradation/transformation products in simulated landfill leachate samples. In vitro bioassays were developed to study for the first time the metabolism of the novel BFRs TBECH by human liver microsomes and EH-TBB and FM550 by human skin S9 fractions. TBECH was metabolised by hepatic CYP450-mediated enzymes to produce a complex mixture of hydroxylated, debrominated and α-oxidation metabolites. EH-TBB and TPhP (in the FM550 mixture) underwent biotransformation by carboxylesterases in human skin S9 fractions. Kinetic modelling of the studied hepatic and dermal human biotransformation reactions revealed that exposure to multiple chemicals significantly influences the metabolic rates of target compounds. In vitro - in vivo extrapolations were also modelled to investigate the xenobiotic clearance capacities of human liver and skin.
TOPICAL NAME USED AS SUBJECT
RA Public aspects of medicine ; TD Environmental technology. Sanitary engineering
PERSONAL NAME - PRIMARY RESPONSIBILITY
Nguyen, Khanh Hoang
CORPORATE BODY NAME - SECONDARY RESPONSIBILITY
University of Birmingham
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب p
[Thesis]
276903
a
Y
