عنوان

Analysis of the behavioural effects of barley and sertraline in two in-vivo models of stress :

Number

TLets732100

Title Proper

Analysis of the behavioural effects of barley and sertraline in two in-vivo models of stress :

General Material Designation

[Thesis]

First Statement of Responsibility

Al-Shehri, M. A. S.

Title Proper by Another Author

anti-depressant and anti-nociceptive effects of barley in mice and sertraline effects on anxiety in the offspring of prenatally-stressed rats

Name of Publisher, Distributor, etc.

University of Bradford

Date of Publication, Distribution, etc.

2015

Dissertation or thesis details and type of degree

Thesis (Ph.D.)

Text preceding or following the note

2015

Text of Note

To prove the post-natal depression model, the antidepressant sertraline, was assessed in rat mothers (n=14) divided into Prenatally Stressed (PS) and Non-Stressed (NS) groups. The data failed to support the hypothesis that 'the progeny of 10mg of sertraline-treated PS mothers displayed less anxiety than the progeny of vehicle-treated PS mothers'. The forced swim test (FST) was used to examine depressive-like behaviour in mice. Barley successfully increased mobility in mice exposed to the FST. Barley was antidepressant at low doses (0.8g/kg and upwards) if used subchronic; and at high doses(6.4g/kg and 12.8g/kg) if used acutely;(n=113,56acute,57 subchronic- treated). Barley (6.4g/kg) was also able to alleviate the depressive-behaviour in mice induced by the Reserpine Test (n=114, 58 reserpinised, 56 non-reserpinised) and Social 'Defeat' Test (n=24, 8 vehicle undefeated, 8 barley defeated, 8 vehicle defeated mice). To confirm that the anti-depressant effects of barley(6.4g/kg) were not simply due to increased locomotor activity in the FST, an Open Field Test(OFT) was undertaken (n=14,7 vehicle, 7 barley). Barley had no effect on locomotor activity and also caused no significant changes in weight (n=16, 8vehicle, 8 barley). In mice,Barley(6.4g/kg) significantly delayed the tremorogenic effects of Physostigmine (n=18, 6 control,6 Physostigmine, 6 Physostigmine with barley); reduced bradykinesia induced by reserpine (n=18,6 control, 6 vehicle, 6 barley treated);and was analgesic in nociception tests (n =20, 5 control, 5 barley, 5 pain, 5 pain with barley). Overall, barley was seen to have many useful properties, though its effect in PND remains to be assessed.

Barley ; Hordeum Vulgare ; Effects ; Reserpine ; Sertraline ; Stress ; Depression ; Pain ; Anxiety

Al-Shehri, M. A. S.

University of Bradford

Electronic name

p

[Thesis]

276903

a

Y