عنوان

DNA binding studies of fluorinated bioactive heterocyclic compounds

Number

TLets639745

Title Proper

DNA binding studies of fluorinated bioactive heterocyclic compounds

General Material Designation

[Thesis]

First Statement of Responsibility

Mojally, Mariam

Name of Publisher, Distributor, etc.

Loughborough University

Date of Publication, Distribution, etc.

2015

Dissertation or thesis details and type of degree

Thesis (Ph.D.)

Text preceding or following the note

2015

Text of Note

Fluorinated heterocyclic compounds have drug like properties and possess a valuable biological activity due to their rigid chemical structures and the high solubility profile. Novel fluorinated heteroarenes have been synthesised by SNAr reaction of a range of fluorinated arenes including pentafluoropyridine, hexafluorobenzene and pentafluorotoluene to introduce a range of groups specially nitriles, benzimidazole, carbazole and benzimidazole. A number of cyclization reactions have been investigated with the aim of forming polycyclic structures that could act as DNA intercalators. The synthesised compounds have been characterized by elemental analysis, IR, 1H and 19F NMR spectroscopy and single crystal analysis. These compounds have been screened for their biological activities including DNA thermal denaturation assay, UV-Visible spectroscopy, fluorescence spectroscopy, X-ray co-crystallization and antimicrobial activity study. Some of the compounds showed potential DNA bonding activity in particular the carbazole derivatives.

Mojally, Mariam

Loughborough University

Electronic name

p

[Thesis]

276903

a

Y