عنوان

Studies of some fused-ring heterocycles and 2,6-Diarylpyridine derivatives

Number

TLets310079

Title Proper

Studies of some fused-ring heterocycles and 2,6-Diarylpyridine derivatives

General Material Designation

[Thesis]

First Statement of Responsibility

Sadiq, Samina

Subsequent Statement of Responsibility

Parrick, J.

Name of Publisher, Distributor, etc.

Brunel University

Date of Publication, Distribution, etc.

1999

Dissertation or thesis details and type of degree

Thesis (Ph.D.)

Text preceding or following the note

1999

Text of Note

This work reported is divided into two parts: the first part deals with quinoxaline derivatives and includes the preparation and characterisation of novel linear tricyclic quinones 1,4-diazanthracen-9,10-diones, (54) and (55). The reaction of diazanaphthoquinones and 1-acetyl-1,3-butadiene are used to produce these quinones through the Diels-Alder reaction. In addition hexaazapentacyclic 5,6,7,12,13, 14-hexaazapentacene was prepared by the reaction ofbis(2-chloroquinoxalin-3-yl)sulfide with thioxamide and the reaction of the sulfide with amines was investigated. Two different approaches to 6,13-dibutyl-5,6,7,12,13,14-hexaazapentacene are given. Derivatives of the pentacyclic, 6-thia- 5,7,12,13,14-pentaazapentacene and the unsubstituted 6,13 -dihydro compound are described. The novel N-(2,5-dimethoxy-6-nitrophenyl)guanidine is used to obtain 3-amino-5,6-dimethoxy-1 ,2,4-benzotriazine-1-oxide and 4,7 -dimethoxy-1 ,2,3 -benzotriazole is shown to be second product. Second part of the work is concerned with the development of a preparative route to 2,6-diphenylpyridines substituted with different groups on the phenyl nuclei. Several approaches were attempted. Finally, success was achieved and a series of compounds having basic chains of different length on the phenyl groups was prepared. One chain in each case had a terminal primary amine. The binding constants of the primary amines and their N-acetyl derivatives with DNA were determined using fluorescence spectroscopy.

Quinoxaline; Anti-cancer agents

Sadiq, Samina

Parrick, J.

Brunel University

Electronic name

p

[Thesis]

276903

a

Y