Surface engineered biosensors for the early detection of cancer
General Material Designation
[Thesis]
First Statement of Responsibility
Muhymin Islam
Subsequent Statement of Responsibility
Iqbal, Samir
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
The University of Texas at Arlington
Date of Publication, Distribution, etc.
2015
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
187
GENERAL NOTES
Text of Note
Committee members: Butler, Donald; Ghosh, Santaneel; Kim, Young-Tae; Magnusson, Robert
NOTES PERTAINING TO PUBLICATION, DISTRIBUTION, ETC.
Text of Note
Place of publication: United States, Ann Arbor; ISBN=978-1-339-42914-4
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
Ph.D.
Discipline of degree
Electrical Engineering
Body granting the degree
The University of Texas at Arlington
Text preceding or following the note
2015
SUMMARY OR ABSTRACT
Text of Note
Cancer commences in the building block of human body which is cells and in most of the cases remains silent at early stage. Diseases are only expressed at molecular and cellular level at primary stages. Recognition of diseases at this micro and nano level might reduce the mortality rate of cancer significantly. This research work aimed to introduce novel electronic biosensors for for identification of cancer at cellular level. The dissertation study focuses on 1) Label-Free Isolation of Metastatic Tumor Cells Using Filter Based Microfluidic device; 2) Nanotextured Polymer Substrates for Enhanced Cancer Cell Isolation and Cell Growth; 3) Nanotextured Microfluidic Channel for Electrical Profiling and Detection of Tumor Cells from Blood; and 4) Single Biochip for the Detection of Tumor Cells by Electrical Profile and Surface Immobilized Aptamer. Standard silicon processing techniques were followed to fabricate all of the biosensors. Nantoextruing and surface functionalizon were also incorporated to elevate the efficiency of the devices.