Addressing Limitations of a Spatially Sensitive Large-Area Ion Chamber for Real-Time Verification of Intensity Modulated Radiation Therapy
General Material Designation
[Thesis]
First Statement of Responsibility
Xun Lin
Subsequent Statement of Responsibility
Islam, Mohammad K.; Heaton, Robert K.
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
University of Toronto (Canada)
Date of Publication, Distribution, etc.
2015
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
95
GENERAL NOTES
Text of Note
Committee members: Coolens, Catherine; Dolan, Alf M.; Jaffray, David A.
NOTES PERTAINING TO PUBLICATION, DISTRIBUTION, ETC.
Text of Note
Place of publication: United States, Ann Arbor; ISBN=978-1-339-28229-9
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
M.H.Sc.
Discipline of degree
Biomedical Engineering
Body granting the degree
University of Toronto (Canada)
Text preceding or following the note
2015
SUMMARY OR ABSTRACT
Text of Note
Lack of light transparency and overall thickness are limitations of a previously described spatially sensitive large-area ionization chamber used for real-time verification of radiation therapy beam delivery. The first limitation was addressed with investigation of a commercially available light transparent conductive glass plates as replacements for aluminum plates in the construction of the chamber. Resulting chamber produced expected spatial sensitivity, allowed the light field to be transmitted with 35% attenuation in intensity, and caused deviation of field position due to refraction up to 0.4 mm. The second limitation was investigated with a novel interleaved comb patterned electrode pairs. The pattern was ablated on a light transparent conductive glass plate and utilized for construction of an experimental prototype ionization chamber that was 35% thinner, light transparent, and produced a spatial sensitivity comparable to the original design. However, further refinement in the design and manufacturing process will be necessary to make a practical comb patterned ionization chamber pair.
TOPICAL NAME USED AS SUBJECT
Biomedical engineering; Biophysics; Oncology
UNCONTROLLED SUBJECT TERMS
Subject Term
Biological sciences;Applied sciences;Health and environmental sciences;Imrt;Large area ionization chamber;Light transparency;Online treatment verification;Real-time quality assurance