عنوان

Target Organ Pathology :

(Number (ISBN

0203481925

(Number (ISBN

9780203481929

Number

b615217

Title Proper

Target Organ Pathology :

General Material Designation

[Book]

Other Title Information

a Basic Text.

First Statement of Responsibility

J Turton

Edition Statement

1st ed

Place of Publication, Distribution, etc.

New York

Name of Publisher, Distributor, etc.

CRC Press

Date of Publication, Distribution, etc.

2003. ©2005

Specific Material Designation and Extent of Item

(456 pages)

Text of Note

Leucocyte biology.

Text of Note

Book Cover --; Half-Title --; Title --; Copyright --; Contents --; Foreword --; Preface --; Contributors --; 1 The Integumentary System --; 1.1 Introduction --; 1.2 Anatomy, Histology and Physiology --; 1.2.1 Epidermis --; Basal layer --; Stratum spinosum --; Stratum granulosum --; Stratum corneum --; 1.2.2 Dermis (Corium) --; 1.2.3 Hypodermis --; 1.2.4 Skin Appendages --; Hair --; Sebaceous glands --; Sweat glands --; 1.3 Biochemical and Cellular Mechanisms of Toxicity --; 1.3.1 Non-Chemical Agents --; Physical damage --; Bacterial, viral and fungal infections --; Nutritional or vitamin deficiencies or excesses --; Inherited disorders --; Radiation --; 1.3.2 Chemical Toxicity --; Barrier properties, percutaneous absorption and toxicity --; Enzymatic activity of the skin --; Properties of chemicals in relation to their mechanism of action --; 1.4 Morphological Response to Injury --; 1.4.1 Changes with Caustic Agents and Skin Irritants --; Primary damage --; Primary epidermal damage --; Primary dermal damage --; Follicular damage --; Inflammatory changes --; Epidermal oedema --; Epidermatitis --; Dermal oedema --; Dermatitis (Figure 1.4c to 1.4e) --; Folliculitis (Figure 1.5a) --; Granulomatous response --; Healing responses --; Epidermal response to damage --; Acanthosis (Figure 1.5b) --; Hyperkeratosis (Figure 1.5c) --; Repair of minor dermal damage --; Repair of epidermal and dermal necrosis --; Repair processes in follicle --; 1.4.2 Responses to Skin Sensitizers (in Sensitized Subjects) --; Contact urticaria --; 1.4.3 Responses to Skin Carcinogens --; Acute responses --; Chronic responses --; Papillomas (Figure 1.6a and 1.6b) --; Keratoacanthomas --; Carcinomas (Figures 1.6c and 1.6d) --; Sarcomas --; Melanotic tumours and melanomas --; 1.5 Testing for Toxicity --; 1.5.1 Preparation of Skin for Histological Examination --; 1.5.2 Skin Irritancy Testing --; 1.5.3 Testing for Skin Sensitizers. 1.5.4 Testing for Skin Carcinogens --; 1.5.5 Subcutaneous Sarcoma --; 1.6 Conclusions --; References --; 2 The Digestive System I: The Gastrointestinal Tract and Exocrine Pancreas --; 2.1 Introduction --; 2.2 Anatomy, Histology and Physiology --; 2.2.1 Anatomy and Histology --; Oral cavity --; Salivary glands --; Oesophagus --; Stomach --; Intestine --; Pancreas --; 2.2.2 Physiology --; Salivation --; Nausea and vomiting --; Gastric secretion and mucosal protection factors --; Intestinal and pancreatic physiology --; 2.3 Biochemical and Cellular Mechanisms of Toxicity --; 2.3.1 Mucosal Exposure to Xenobiotics --; 2.3.2 Mucosal Absorption Pathways --; 2.3.3 Mucosal Metabolism --; 2.3.4 Gut Microflora Metabolism --; 2.3.5 Motility Disorders --; 2.3.6 Accumulation Enteropathies --; 2.3.7 Nutritional Factors --; 2.4 Morphological Responses to Injury --; 2.4.1 Oral Cavity --; 2.4.2 Salivary Glands --; 2.4.3 Oesophagus and Non-Glandular Forestomach --; 2.4.4 Glandular Stomach --; 2.4.5 Small and Large Intestine --; 2.4.6 Exocrine Pancreas --; 2.5 Testing for Toxicity --; 2.6 Conclusions --; References --; 3 The Digestive System II: The Hepatobiliary System --; 3.1 Introduction --; 3.2 Anatomy, Histology and Physiology --; 3.2.1 Anatomy --; 3.2.2 Histology --; 3.2.3 Physiology --; 3.3 Biochemical and Cellular Mechanisms of Toxicity --; 3.3.1 Hepatocellular Toxicity --; Toxins requiring metabolic activation --; CYP mediated --; Alcohol dehydrogenase mediated --; 3.3.2 Biliary Toxicity --; 3.3.3 Immune-mediated Toxicity --; Halothane --; 3.4 Morphological Responses to Injury --; 3.4.1 Acute Injury --; Site --; Degree --; Cytology --; Ultrastructure --; 3.4.2 Chronic Injury --; 3.4.3 Hypertrophy and Hyperplasia --; 3.4.4 Carcinogenesis --; Development of hepatocellular neoplasia in rodents --; Other hepatic neoplasms --; 3.4.5 Mechanisms of Neoplasia --; Cenotoxic carcinogens. Non-genotoxic carcinogens --; 3.5 Testing for Toxicity --; 3.5.1 Clinical Chemistry --; Plasma proteins --; Serum enzymes --; 3.5.2 Necropsy and Histopathological Examination --; 3.5.3 In vitro Systems --; 3.6 Conclusions --; References --; 4 The Urinary System --; 4.1 Introduction --; 4.2 Anatomy, Histology and Physiology --; 4.2.1 Blood Supply --; 4.2.2 Nephron --; 4.2.3 Glomerulus --; 4.2.4 Proximal Tubule --; 4.2.5 Loop of Henle --; 4.2.6 Distal Tubule --; 4.2.7 Collecting Duct System --; 4.2.8 Juxtaglomerular Apparatus --; 4.2.9 Interstitium --; 4.2.10 Renal Pelvis --; 4.2.11 Ureter and Bladder --; 4.3 Biochemical and Cellular Mechanisms of Toxicity --; 4.3.1 Glomerular Damage --; 4.3.2 Renal Tubular Injury --; 4.3.3 Interstitial Damage --; 4.3.4 Urothelial Injury --; 4.3.5 --; 4.3.6 Neoplasia --; 4.4 Morphological Responses to Injury --; 4.4.1 Renal Weight Changes --; 4.4.2 Glomerular Hypertrophy --; 4.4.3 Glomerular Atrophy --; 4.4.4 Glomerulonephritis --; Heyman nephritis --; 4.4.5 Glomerular Vacuolation --; 4.4.6 Glomerular Sclerosis (induding chronic progressive nephropathy in rats) --; 4.4.7 Amyloidosis --; 4.4.8 Tubular Necrosis --; 4.4.9 Tubular Vacuolation --; 4.4.10 Hydropic Change --; 4.4.11 Large Clear Vacuoles --; 4.4.12 Tubular Hyaline Droplets --; 4.4.13 Tubular Crystal Deposition --; 4.4.14 Pigmentation of Tubular Cells --; 4.4.15 Tubular Nuclear Inclusions --; 4.4.16 Tubular Hypertrophy --; 4.4.17 Tubular Hyperplasia --; 4.4.18 Interstitial Nephritis --; 4.4.19 Vascular Changes and Infarction --; 4.4.20 Hypertrophy and Hyperplasia of the Juxtaglomerular Apparatus --; 4.4.21 Papillary Necrosis --; 4.4.22 Mineralization --; 4.4.23 Hydronephrosis --; 4.4.24 Pyelonephritis --; 4.4.25 Renal Neoplasia --; Adenoma and adenocarcinoma --; Nephroblastoma --; Mesenchymal tumour --; Oestrogen-induced renal tumour of the hamster. Transitional cell or urothelial tumour --; 4.4.26 Inflammation of the Urinary Bladder, Cystitis --; 4.4.27 Bladder Mineralization, Calcification, Calculi, Stones --; 4.4.28 Urothelial Hyperplasia --; 4.4.29 Neoplasia of the Urinary Bladder --; Transitional cell papilloma --; Transitional cell carcinoma --; Other tumour types --; 4.5 Testing for Toxicity --; 4.6 Conclusions --; References --; 5 The Cardiovascular System --; 5.1 Introduction --; Section A: The Heart --; 5.2 Anatomy, Histology and Physiology --; 5.2.1 Gross Anatomy --; 5.2.2 Histology --; Myocardium --; Myocytes --; Conducting fibres --; Interstitial tissues --; Pericardium --; Endocardium --; Cardiac valves --; 5.2.3 Physiology --; Cardiac impulse --; Exdtation-contraction coupling --; Myocardial metabolism --; Nervous control of the heart --; 5.3. Biochemical and Cellular Mechanisms of Toxicity --; 5.3.1 Developmental Abnormalities --; 5.3.2 Physiological Mechanisms --; Effects on ion movement --; 5.3.3 Biochemical Mechanisms --; 5.3.4 Pharmacological Mechanisms --; 5.3.5 Immunologically Mediated Toxicity --; 5.4 Morphological Responses to Injury --; 5.4.1 Non-neoplastic Changes --; No morphological change --; Scar formation --; Hypertrophy --; Atrophy --; Necrosis --; Infarction --; Mineralization --; Vacuolar degeneration --; Myocytolysis --; Fatty change --; Lipofuscin pigment --; Endocardial and epicardial changes --; Atrial lesions --; Thrombi --; 5.4.2 Tumours --; Spindle cell tumours --; Other tumours --; 5.4.3 Spontaneous Pathology --; 5.5 Testing for Toxicity --; 5.5.1 Physiological Methods --; 5.5.2 Plasma and Serum Enzymes --; 5.5.3 Morphological Methods --; Necropsy --; Tissue sampling --; Staining --; Histopathology --; 5.5.4 Special Techniques --; Electron microscopy --; Other techniques --; Section B: The Vascular System --; 5.2 Anatomy, Histology and Physiology --; 5.2.1 Anatomy --; 5.2.2 Histology.

Text of Note

Elastic (conducting) arteries --; Muscular (distributing) arteries --; Arterioles --; Capillaries --; Veins --; Lymphatic vessels and capillaries --; Anatomical and physiological variations --; Spedalized structures --; Endothelium --; Vascular smooth muscle --; Connective tissues --; Blood --; 5.2.3 Physiology --; Nervous and humoral control of vessels --; 5.3 Biochemical and Cellular Mechanisms of Toxicity --; 5.3.1 Developmental Abnormalities --; 5.3.2 Biochemical Mechanisms --; 5.3.3 Physiological Mechanisms --; 5.3.4 Pharmacological Mechanisms --; 5.3.5 Immunologically Mediated Toxicity --; 5.4 Morphological Responses to Injury --; 5.4.1 Non-neoplastic Changes --; Haemodynamic changes --; Atherosclerosis --; Intimal proliferation --; Medial necrosis --; Medial hypertrophy --; Adventitial oedema, haemorrhage and fibrosis --; Fibrinoid necrosis --; Arteritis/periarteritis --; Capillary damage --; Hypersensitivity angiitis --; Mineralization --; Amyloidosis --; Thrombi --; 5.4.2 Tumours --; Haemangioma --; Haemangiosarcoma --; Other tumours --; 5.4.3 Spontaneous Pathology --; Beagle pain syndrome --; Extramural coronary arteritis --; Arteritis/periarteritis --; 5.5 Testing for Toxicity --; 5.5.1 Physiological Methods --; Blood pressure and flow measurements --; 5.5.2 Morphological Methods --; Necropsy --; Intravascular studies --; Tissue sampling --; Staining --; Histopathology --; 5.5.3 Special Techniques --; Electron microscopy --; Tracers --; Isolated vascular beds in vivo and ex vivo --; Isolated vascular muscle strips --; Tissue culture --; 5.6 Conclusions --; References --; Additional Reading --; 6 The Haematopoietic System --; 6.1 Introduction --; 6.2 Anatomy, Histology and Physiology --; 6.2.1 Anatomy --; Bone marrow --; Spleen and lymphoreticular tissue --; Blood --; Erythrocyte development --; Leucocyte development --; Platelet formation --; 6.2.2 Histology --; 6.2.3 Physiology --; Erythrocyte biology.

Text of Note

The major organs of the body are targets for chemically-induced effects in animals and humans. This book reviews the mechanisms of these toxic effects and the structure/functional changes which occur in the target organ tissues as a result.

Target organs (Anatomy)

Toxicology.

Class number

Book number

J Turton

J Hooson

J Turton

Electronic name

[Book]

Y