عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
INTERNATIONAL STANDARD BOOK NUMBER
(Number (ISBN
9780123850348
NATIONAL BIBLIOGRAPHY NUMBER
Number
b606424
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Evolution of Human Papillomavirus Carcinogenicity-Chapter 2
General Material Designation
[Book]
First Statement of Responsibility
Koenraad Van Doorslaer
SUMMARY OR ABSTRACT
Text of Note
Members of the Alphapapillomavirus genus are the causative agent for virtually all cases of cervical cancer. However, strains (commonly referred to as types) within this genus span the entire range of pathogenicity from highly carcinogenic (e.g., HPV16, odds ratio in vitro. A plethora of functions have been described for both oncoproteins, and through functional comparisons between HPV16 and HPV6, a subset of these functions have been suggested to be oncogenic. However, extrapolating functional differences from these comparisons is unlikely to tease apart the fine details. In this review, we argue that a thorough understanding of the molecular mechanisms differentiating oncogenic from nononcogenic types should be obtained by performing functional assays in an evolutionary and epidemiological framework. We continue by interpreting some recent results using this paradigm and end by suggesting directions for future inquiries.
PERSONAL NAME - PRIMARY RESPONSIBILITY
Koenraad Van Doorslaer
PERSONAL NAME - ALTERNATIVE RESPONSIBILITY
Koenraad Van Doorslaer
Robert D Burk Affiliation: Department Obstetrics, Gynecology and Woman's Health, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, USA
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب [Book]
Y
