Quantitative Aspects of Growth and Metabolism of Microorganisms
General Material Designation
[Book]
First Statement of Responsibility
edited by A.H. Stouthamer.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Dordrecht
Name of Publisher, Distributor, etc.
Springer Netherlands
Date of Publication, Distribution, etc.
1992
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
(iii, 382 pages)
CONTENTS NOTE
Text of Note
Editorial.- Quantitation of microbial metabolism.- Quantifying heterogeneity: flow cytometry of bacterial cultures.- Microbial growth dynamics on the basis of individual budgets.- Quantitative aspects of cellular turnover.- Quantitative approaches to the analysis of the control and regulation of microbial metabolism.- Quantification of control of microbial metabolism by substrates and enzymes.- On multiple-nutrient-limited growth of microorganisms, with special reference to dual limitation by carbon and nitrogen substrates.- A new thermodynamically based correlation of chemotrophic biomass yields.- The use of stoichiometric relations for the description and analysis of microbial cultures.- Application of a metabolic balancing technique to the analysis of microbial fermentation data.- Metabolite production and growth efficiency.- Determination of the maximum product yield from glucoamylase-producing Aspergillus niger grown in the recycling fermentor.- Physiology of yeasts in relation to biomass yields.- Formation of fermentation products and extracellular protease during anaerobic growth of Bacillus licheniformis in chemostat and batch-culture.- Quantitative aspects of glucose metabolism by Escherichia coli B/r, grown in the presence of pyrroloquinoline quinone.
SUMMARY OR ABSTRACT
Text of Note
Application of recent advances, such as non-equilibrium thermodynamics, the maintenance concept and the material balancing method, to the description, of microbial growth has suggested new experimental approaches which have yielded a wealth of data. These data have been used to develop mathematical models of microbial growth and metabolism, and the models have made it possible to direct the metabolism of a microorganism in such a way that more of a certain desired product is made. While a full quantitative description of all aspects of microbial growth and metabolism is till remote, the new approaches are opening up large areas of new potential -- it is now possible, for instance, to deal with individual cells in a population and with quantitative aspects of product formation and optimisation. Microbiologists, biochemists and physiologists will find this an invaluable update on a field of great promise.