عنوان

Nuclear factor kB :

(Number (ISBN

9401001634

(Number (ISBN

9401039836

(Number (ISBN

9789401001632

(Number (ISBN

9789401039833

Number

b594199

Title Proper

Nuclear factor kB :

General Material Designation

[Book]

Other Title Information

regulation and role in disease

First Statement of Responsibility

edited by Rudi Beyaert.

Place of Publication, Distribution, etc.

Dordrecht

Name of Publisher, Distributor, etc.

Springer Netherlands : Imprint : Springer

Date of Publication, Distribution, etc.

2003

Specific Material Designation and Extent of Item

(XI, 426 pages)

Text of Note

Activators and Target Genes of Rel/NF-?B Transcription Factors --; From Bench to Bedside --; NF-?B Activation by Tumor Necrosis Factor and Interleukin-1 --; NF-?B Activation by CARD Proteins --; Viruses as Intruders in the Rel/NF-?B Signaling Pathway --; The I?B Kinase (IKK) Complex --; The Role of Ubiquitin in NF-?B Signaling --; New Insights into the Regulation of NF-?B --; Roles for Phosphorylation and Acetylation of NF-?B Subunits --; The Structural Biology of NF-?B --; Tools to Interfere with NF-?B Activation --; Regulation of NF-?B by Glucocorticoids --; Genetic Analysis of NF-?B-dependent Signaling Pathways in Mammalian Cells --; Delineation of NF-?B Signaling by Gene Targeting --; The Role of NF-?B in Inflammatory Diseases --; NF-?B in Genetic Disorders --; NF-?B in the Vascular System --; NF-?B in T-lymphocyte Biology --; NF-?B in the Nervous System --; NF-?B in Oncogenesis and as a Target for Cancer Therapy --; Control of Immunity by Rel Proteins in Drosophila.

Text of Note

The transcription factor NF-kappaB and the signaling pathways regulating its activity constitute a paradigm of membrane to nucleus communication. NF-kappaB is central to a number of cellular functions including cell proliferation, apoptosis, and cellular differentiation. This transcription factor also plays essential roles in innate and acquired immunity, and its deregulation leads to important human diseases such as inflammation and cancer. Therefore NF-kappaB, together with the signaling pathways leading to its activation, constitute an attractive therapeutic target. This book is the first to review and synthesize our knowledge on this interesting transcription factor. It will be of great interest for those entering or already actively working in the NF-kappaB field, as well as a valuable reference for students, established researchers, or clinicians with wider interests in the fields of molecular cell biology and biomedicine.

Immunology.

Medicine.

Oncology.

Class number

Book number

edited by Rudi Beyaert.

Rudi Beyaert

Electronic name

[Book]

Y