1. Anatomy of the mitral valvular complex / Nicolas M. Van Mieghem, Jackie S. McGhie, and Margot M. Bartelings --; 2. The pathophysiology of mitral regurgitation / Blase A. Carabello --; 3. Genesis of the surgical edge-to-edge repair / Ottavio Alfieri and Michele De Bonis --; 4. Outcomes from surgical edge-to-edge repair / Francesco Maisano --; 5. An overview of the literature on surgical mitral valve repair / Sophie Jones, Michael Argenziano, and Allan Schwartz --; 6. Development of percutaneous edge-to-edge repair : the MitraClipʼ story / Frederick St. Goar --; 7. MitraClipʼ system design and history of development / Troy Thornton and Liz McDermott --; 8. The EVEREST trial results / Alice Perlowski and Ted Feldman --; 9. Outcomes for functional mitral regurgitation / James Hermiller, Douglas Segar, David Heimansohn, and Nauman Siddiqi --; 10. The role of percutaneous mitral repair for high risk patients / Willis Wu and Patrick Whitlow --; 11. Echocardiographic evaluation for mitral regurgitation grading and patient selection / Ehrin J. Armstrong and Elyse Foster --; 12. Understanding the limits of patient selection for edge-to-edge repair / Ehrin J. Armstrong and Jason H. Rogers --; 13. The basic technique for the Evalve MitraClipʼ procedure / Gretchen Gary and Ted Feldman --; 14. Procedural tips and tricks / Saibal Kar and Wen-Loong Yeow --; 15. Training and simulation / Scott Lim --; 16. Special techniques for functional mitral regurgitation / Olaf Franzen, Stephan von Bardeleben, and Susanna Price --; 17. The European experience since CE approval / Corrado Tamborino, Gian Paolo Ussia, and Valeria Cammalleri. 18. An interventionalist's approach to the practical use of TEE guidance / Howard C. Herrmann --; 19. Echocardiographic guidance of MitraClipʼ mitral valve repair / Frank E. Silvestry --; 20. A critical appraisal of edge-to-edge repair with the MitraClipʼ / Peter C. Block --; 21. Technique for surgical removal of the MitraClipʼ / Lori Soni and Michael Argenziano --; 22. Special considerations for mitral valve repair after clip therapy / Subhasis Chatterjee, David A. Heimansohn, and John C. Alexander --; 23. Gross and histologic findings after MitraClipʼ placement / Elena Ladich, Masataka Nakano, and Renu Virmani --; 24. Future directions in percutaneous mitral therapy / Ted Feldman and Frederick St. Goar.