Epigenetics - What it is and Why it Matters; Enzyme and Protein Families that Regulate Histone Modifications and Crosstalk; Epigenetics and Disease; Targeting DNA Methylation; Targeting Histone Acetylation; Targeting Histone Lysine Methyltransferases in Cancer; Targeting Non-Acetylation Histone Erasers; Progress in Targeting Epigenetic Readers; Who will Bebefit from Epigenetic Drugs; Dosing - When Less Is More; Histone Methyltransferase Activity Assays; Safety Considerations for Epigenetic Mechanisms as Drug Targets: Are Existing Toxicology Studies Fit for Purpose?;