History and Introduction --; The Chemistry of the Quinolones: Methods of Synthesizing the Quinolone Ring System --; Chemistry in the Periphery of the Quinolones --; Mode of Action --; The In Vitro Antibacterial Activity of Quinolones: A Review --; Pharmacokinetics of Fluoroquinolones in Experimental Animals --; Pharmacodynamics of Fluoroquinolones in Experimental Animals --; Interaction of Quinolones with Host-Parasite-Relationships --; Mechanisms of Resistance to Fluoroquinolones --; Toxicology and Safety Pharmacology of Quinolones --; Clinical Pharmacology --; Concentration-Effect Relationship of the Fluoroquinolones --; Clinical Use of Quinolones --; Future Aspects.
SUMMARY OR ABSTRACT
Text of Note
The quinolones continue to make a significant contribution in the fight against community or hospital acquired infections and add a new dimension of antibacterial therapy. This volume describes in detail the chemistry, mode of action and pharmacodynamics of the quinolones. A lot of effort has been undertaken to optimize structure-activity relationships with the aim of producing more potent drugs with an optimal therapeutic index.
TOPICAL NAME USED AS SUBJECT
Anti-Infective Agents -- therapeutic use.
Quinolone antibacterial agents.
Quinolones -- pharmacology.
LIBRARY OF CONGRESS CLASSIFICATION
Class number
QP905
Book number
.
C668
1998
PERSONAL NAME - PRIMARY RESPONSIBILITY
contributors, D. Beermann [and others] ; editors, J. Kuhlmann, A. Dalhoff, and H.-J. Zeiler.