عنوان

Idiopathic Dilated Cardiomyopathy :

(Number (ISBN

3642778917

(Number (ISBN

9783642778919

Number

b573737

Title Proper

Idiopathic Dilated Cardiomyopathy :

General Material Designation

[Book]

Other Title Information

Cellular and Molecular Mechanisms, Clinical Consequences

First Statement of Responsibility

edited by Hans-Reiner Figulla, Reinhard Kandolf, Bruce McManus.

Place of Publication, Distribution, etc.

Berlin, Heidelberg

Name of Publisher, Distributor, etc.

Springer Berlin Heidelberg

Date of Publication, Distribution, etc.

1993

Specific Material Designation and Extent of Item

(xvi, 405 pages 117 illustrations, 5 illustrations in color.)

Text of Note

I. Introductory Perspectives --; Idiopathic Dilated Cardiomyopathy: Current Concepts in Clinical Research --; II. Epidemiology and Natural Course of IDC --; Epidemiology of Idiopathic Dilated Cardiomyopathy --; Natural History of Idiopathic Dilated Cardiomyopathy --; III. Basic Molecular Concepts Toward Understanding of IDC --; Molecular Analysis of Cardiac Growth and Development in Transgenic Mouse Model Systems --; The Promoter of the Human Cardiac?-Myosin Heavy-Chain Gene Is Controlled by an Upstream Enhancer --; Growth Factor Expression in the Cardiac Myocyte --; IV. Structural Abnormalities in IDC --; The Cytoskeleton and Extracellular Matrix in Human Hearts with Dilated Cardiomyopathy --; Macro- and Micropathology of Dilated Cardiomyopathy --; Detection of Disruption of Sarcolemmal Membrane by Indium-111 Labeled Antimyosin Antibody Scan --; Extracellular Matrix Expression, Organization, and Interaction with Heart Myocytes During Development and Disease --; V. Contraction and Relaxation --; Ventricular Remodeling in Idiopathic Dilated Cardiomyopathies --; Mechanisms of Deficient cAMP Generation in Heart Failure --; Abnormal Calcium Metabolism in Heart Muscle Dysfunction --; Energy Requirements of Contraction and Relaxation of the Heart --; VI. Microcirculation and Oxygen Supply in Cardiac Hypertrophy and IDC --; Capillary Density, Distribution, and Length Parameters Related to Oxygen Supply in Myocardial Hypertrophy and Atrophy --; Microcirculation in the Cardiomyopathic Syrian Hamster and in Human Congestive Cardiomyopathy --; The Microcirculation in Cardiac Hypertrophy --; Myocardial Oxygen Consumption in Patients with Idiopathic Dilated Cardiomyopathy: Effects of Vasodilating and Inotropic Agents --; Regression of Cardiac Hypertrophy with Pharmacotherapeutic Regimen --; VII. Ionic Channels and Signal Gating --?-Adrenergic Receptor Dysfunction in the Pathogenesis of Idiopathic Dilated Cardiomyopathy --; Na+ Channels as Molecular Substrate of Cardiac Excitability: Elementary Properties and Responsiveness to Drugs --; The Involvement of Gs in Regulation of the L-Type Voltage-Gated Ca2+ Channel --; Inositol Phosphates in Cardiac Regulation --; VIII. Virus and Cardiomyopathy --; Enterovirus-Induced Cardiomyopathy: Molecular Analysis of Acute and Persistent Myocardial Infections --; Direct Damage of Myocardium by Enterovirus --; Natural History of Enterovirus Persistence in the Murine Model of Coxsackievirus-Induced Myocarditis: A Quantitative In Situ Hybridization and Immunohistochemistry Study --; Detection and Typing of Enteroviruses --; Specific and Nonspecific Heart Defenses in Enteroviral Infections --; IX. Immunological Factors in Cardiomyopathy --; Heart Autoantibodies in Human Myocarditis and Cardiomyopathy: Virus and Skeletal Muscle Cross-reactivity --; Are Anti-cardiac Antibodies in Dilated Cardiomyopathy 'Natural' Antibodies? --; X. Therapeutic Options in IDC and Myocarditis --; Animal Models for Therapeutic Trials of Viral Myocarditis --; Immunosuppressive Therapy in Human Myocarditis --; Interferon Therapy in Enterovirus-Associated Idiopathic Dilated Cardiomyopathy --; The Role of?-Blockers in Idiopathic Dilated Cardiomyopathy: Clinical Effect and Molecular Mechanism --; The Role of Calcium Channel Blockers in Idiopathic Dilated Cardiomyopathy --; Gene Therapy for Cardiovascular Disease: Realistic Possibilities for the Future.

Text of Note

The latest developments in molecular biology have broadened our understanding of the pathogenesis of idiopathic dilated cardiomyopathy (IDC). In this book, written by well-known experts, a comprehensive overviewof IDC is given, including basic cellular and molecular concepts, virology, immunology, cardiac receptors and ionic channels, contractility abnormalities, microcirculation, and oxygen supply in cardiac hypertrophy. Details on basic research are supplemented by results of new clinical trials in IDC and the latest data on the epidemiology of the disease. For those who are interested in the disease, the book summarizes progress in all major fields.

Cardiology.

Human physiology.

Medicine.

Class number

Book number

edited by Hans-Reiner Figulla, Reinhard Kandolf, Bruce McManus.

Bruce McManus

Hans-Reiner Figulla

Reinhard Kandolf

Electronic name

[Book]

Y