عنوان

Epidemiology and Biology of Multiple Myeloma

(Number (ISBN

3642766552

(Number (ISBN

9783642766558

Number

b573545

Title Proper

Epidemiology and Biology of Multiple Myeloma

General Material Designation

[Book]

First Statement of Responsibility

edited by G. Iris Obrams, Michael Potter.

Place of Publication, Distribution, etc.

Berlin, Heidelberg

Name of Publisher, Distributor, etc.

Springer Berlin Heidelberg

Date of Publication, Distribution, etc.

1991

Specific Material Designation and Extent of Item

(xv, 192 pages 30 illustrations)

Text of Note

Descriptive and Analytical Epidemiology of Multiple Myeloma --; Descriptive Epidemiology of Multiple Myeloma --; Epidemiologic Studies of Multiple Myeloma: Occupational and Radiation Effects --; Multiple Myeloma in Iowa Farmers --; Risk of Multiple Myeloma, Allergies and Agricultural Exposures --; Leads for Future Studies from a Case-Control Study of Occupational Exposures and Multiple Myeloma in Denmark --; Familial and Genetic Associations --; Black/White Differences in Risk of Multiple Myeloma --; Racial Variations in Immune Function and Hematological Parameters: Description of Study Design and Objectives --; The Influence of Race on T-Cell Subset Distributions --; Investigating Risk Factors for Multiple Myeloma among Black and White Americans --; Race and Socioeconomic Status Differences in Multiple Myeloma Survival --; Use of Veterans Administration Data to Identify Possible Risk Factors for Multiple Myeloma among Blacks and Whites --; Multiple Myeloma in Sub-Sahara Africa --; Monoclonal Gammopathies and Multiple Myeloma --; Case Definition: Issues Related to Monoclonal Gammopathies and Multiple Myeloma --; The Frequency of Monoclonal Gammopathy of Unknown Significance in Black and Caucasian Veterans in a Hospital Population --; Racial Differences in the Expression of Shared Idiotypes by Paraproteins from Patients with Monoclonal Gammopathies --; Etiologic Hypotheses --; Is Chronic Antigenic Stimulation Etiologically Related to Multiple Myeloma? --; The Etiology of Multiple Myeloma: A Role for Viruses? --; Clinical Studies --; Biology of Multiple Myeloma --; An Overview --; Open Discussion on the Biology of Multiple Myeloma. Chairman's Introductory Remarks --; In Vitro Studies Provide Evidence that Multiple Paracrine Loops may be Operating in Multiple Myeloma --; The Origin of Bone Marrow Plasma Cells --; Cytogenetic Abnormalities in Multiple Myeloma --; Multiple Myeloma Evolves from a Malignant Hematopoietic Stem Cell --; Amylase-Producing Multiple Myeloma --; Experimental Studies --; The C57BL/KaLwRij Mouse Model of B-Cell Proliferative Disorders. Is there a relationship between benign monoclonal gammapathy and multiple myeloma? --; Louvain Rats and Their Immunocytomas --; Induced Plasmacytoma Formation in Mice.

Text of Note

There have been large increases in the incidence of multiple myeloma over the past thirty years, especially with regard to older individuals and blacks. The most striking epidemiologic finding is the two-fold higher incidence in blacks compared to whites. Among hematopoietic malignancies, multiple myeloma is the only one with increased incidence and mortality rates among blacks. In a workshop sponsored by the National Cancer Institute in March last year, the epidemiology of multiple myeloma was covered in depth. The papers included in this volume address differences in immunologic factors and in risk factors for multiple myeloma between blacks and whites, describe the monoclonal gammopathies and their progression to myeloma, and speculate on hypotheses regarding the etiology and pathogenesis of this challenging malignancy. Ques- tions that are addressed include whether neoplastic change occurs at the level of the plasma cell or earlier in the B-cell lineage, the role of inappropriate gene expression, the importance of IL-6 production, and new findings regarding the cytogenetics of this malignancy. Key directions for new research on multiple myeloma and related malignancies are suggested.

Hematology.

Medicine.

Oncology.

Class number

Book number

edited by G. Iris Obrams, Michael Potter.

G Iris Obrams

Michael Potter

Electronic name

[Book]

Y