عنوان

Chemical Carcinogenesis and Mutagenesis I

(Number (ISBN

3642747752

(Number (ISBN

9783642747755

Number

b573320

Title Proper

Chemical Carcinogenesis and Mutagenesis I

General Material Designation

[Book]

First Statement of Responsibility

edited by Colin S. Cooper, Philip L. Grover.

Place of Publication, Distribution, etc.

Berlin, Heidelberg

Name of Publisher, Distributor, etc.

Springer Berlin Heidelberg

Date of Publication, Distribution, etc.

1990

Specific Material Designation and Extent of Item

(xxviii, 604 pages 86 illustrations)

Series Title

Handbook of experimental pharmacology, 94 / 1.

Text of Note

I. Theories of Carcinogenesis --; 1 Mechanisms of Chemical Carcinogenesis: Theoretical and Experimental Bases --; II. Exposure to Chemical Carcinogens --; 2 Environmental Carcinogens --; 3 Advances in Tobacco Carcinogenesis --; 4 Occupational Carcinogens --; 5 Therapeutic Agents as Potential Carcinogens --; III. In Vivo and In Vitro Carcinogenesis --; 6 In Vivo Testing for Carcinogenicity --; 7 Transformation of Cells in Culture --; IV. Reactions of Carcinogens with DNA --; 8 Metabolic Activation and DNA Adducts of Aromatic Amines and Nitroaromatic Hydrocarbons --; 9 Polycyclic Aromatic Hydrocarbons: Metabolism, Activation and Tumour Initiation --; 10 Interactions of Fungal and Plant Toxins with DNA: Aflatoxins, Sterigmatocystin, Safrole, Cycasin, and Pyrrolizidine Alkaloids --; 11 N-Nitroso Compounds --; 12 Heterocyclic-Amine Mutagens/Carcinogens in Foods --; 13 Modem Methods of DNA Adduct Determination --; 14 Biological Consequences of Reactions with DNA: Role of Specific Lesions.

Text of Note

This handbook - the first of two complementary volumes - presents carcinogenesis and mutagenesis. To this end the subject matter covers theories behind the process of carcinogenesis, the ways in which such compounds are metabolized and interact with DNA and the detection and consequences of adduct formation. Relationships between mutagenesis and carcinogenesis are explored together with methods by which chemicals may be tested for mutagenic or carcinogenic properties and how these effects may be modified. Oncogenes and their activation are considered together with the mechanisms by which their role in carcinogenesis is effected. The volume is of broad interest to toxicologists and pharmacologists and of special appeal to graduate and post-graduate research workers studying carcinogenesis and mutagenesis. It is the first attempt to cover the entire range of carcinogenesis, from epidemiology to the effects of oncogenes on cellular differentiation, and contains excellent contributions from leading scientists. The handbook thus provides specialists in defined areas of cancer research with up-to-date overviews of adjacent areas.

Medicine.

Pharmacy.

Toxicology.

Class number

Book number

edited by Colin S. Cooper, Philip L. Grover.

Colin S Cooper

Philip L Grover

Electronic name

[Book]

Y