عنوان

Current Topics in Microbiology and Immunology :

(Number (ISBN

3642661017

(Number (ISBN

3642661033

(Number (ISBN

3642661939

(Number (ISBN

3642661955

(Number (ISBN

9783642661013

(Number (ISBN

9783642661037

(Number (ISBN

9783642661938

(Number (ISBN

9783642661952

Number

b572240

Title Proper

Current Topics in Microbiology and Immunology :

General Material Designation

[Book]

Other Title Information

Ergebnisse der Mikrobiologie und Immunitätsforschung

First Statement of Responsibility

edited by W. Arber, W. Henle, P.H. Hofschneider, J.H. Humphrey, N.K. Jerne, P. Koldovský, H. Koprowski, O. Maaløe, R. Rott, H.G. Schweiger, M. Sela, L. Syruček, P.K. Vogt.

Place of Publication, Distribution, etc.

Berlin, Heidelberg

Name of Publisher, Distributor, etc.

Springer Berlin Heidelberg

Date of Publication, Distribution, etc.

1975

Specific Material Designation and Extent of Item

(volumes)

Series Title

Current topics in microbiology and immunology, 72.

Text of Note

Theoretical Aspects of Structure and Assembly of Viral Envelopes --; Latent Herpes Simplex Virus and the Nervous System --; Temperature-Sensitive Mutants of Herpesviruses --; Inhibition of the Multiplication of Enveloped Viruses by Glucose Derivatives.

Text of Note

The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus group necessitates a description, albeit brief, of the properties of the group and, most importantly, of their genetic material. The herpesviruses comprise a group of relatively large (100-150 nm), enveloped viruses. The envelope surrounds an icosahedral capsid enclosing a core which contains doubleƯ stranded DNA (ROIZMAN, 1969). The group is thus defined on the basis of a common virion morphology. In addition to a common structure, members of the group share a number of biological properties such as a similar replicative cycle, the ability to cause latent and chronic infections, and the ability to induce antigenic modifications of infected cell membranes. Several herpesƯ viruses have been associated recently with malignancies in man and animals (KLEIN, 1972). Herpesviruses are ubiquitous and have been described in over 30 different species (HUNT and MELENDEZ, 1969; WILDY, 1971; FARLEY et aI., 1972; KAZAMA and SCHORNSTEIN, 1972; NAHMIAS et aI., 1972; ROlZMAN et aI., 1973). Their widespread occurrence in nature suggests a common ancestor.

Life sciences.

Medicine.

edited by W. Arber, W. Henle, P.H. Hofschneider, J.H. Humphrey, N.K. Jerne, P. Koldovský, H. Koprowski, O. Maaløe, R. Rott, H.G. Schweiger, M. Sela, L. Syruček, P.K. Vogt.

H G Schweiger

H Koprowski

J H Humphrey

L Syruček

M Sela

N K Jerne

O Maaløe

P H Hofschneider

P K Vogt

P Koldovský

R Rott

W Arber

W Henle

Electronic name

[Book]

Y