General AspectsViral Hemorrhagic Fevers: History and Definitions; Jens H. Kuhn, Anna N. Clawson, Sheli R. Radoshitzky, Victoria Wahl-Jensen,Sina Bavari, and Peter B. JahrlingGeneral Disease Pathology in Filoviral and Arenaviral Infections; Louis M. Huzella, Jennifer A. Cann, Matthew Lackemeyer, Victoria Wahl-Jensen, Peter B. Jahrling, Jens H. Kuhn, and Donna L. PerryInteraction of the Host Immune System with Hemorrhagic Fever Viruses; Gavin C. BowickVascular Endothelium and Hemorrhagic Fever Viruses; Nadine A. Dalrymple, Elena Gorbunova, Irina Gavrilovskaya, and Erich R. MackowVascular Endothelial Dysfunctions: Viral Attack and Immunological Defense; Jayashree Apurupa Lahoti, Ritu Mishra, and Sunit Kumar SinghAnimal Models of Viral Hemorrhagic Fevers; Amy C. Shurtleff, Travis K. Warren, Derek Morrow, Sheli R. Radoshitzky, Jens H. Kuhn, and Sina BavariRole of Rodents and Bats in Human Viral Hemorrhagic Fevers; Victoria Wahl-Jensen, Sheli R. Radoshitzky, Fabian de Kok-Mercado,Shannon L. Taylor, Sina Bavari, Peter B. Jahrling, and Jens H. KuhnBiosafety Issues and Clinical Management of Hemorrhagic Fever Virus Infections; George F. Risi and Thomas ArminioBSL4 Workforce Preparedness in Hemorrhagic Fever Outbreaks; Sean G. KaufmanMajor Strategies for Prevention and Control of the Viral Hemorrhagic Fevers; Matthew L. Boulton and Eden V. WellsPractical Considerations for Collection and Transportationof Hemorrhagic Fever Samples; Manfred Weidmann and Mandy ElschnerLaboratory Diagnosis of Viral Hemorrhagic Fevers; Miroslav Fajfr and Daniel RuzekVaccine Research Efforts for Hemorrhagic Fever Viruses; Shannon S. Martin and Mary Kate HartSpecific InfectionsPathogenic Old World Arenaviruses; Jason Botten, Benjamin King, Joseph Klaus, and Christopher ZieglerLassa Fever; Daniel G. Bausch, Lina M. Moses, Augustine Goba, Donald S. Grant, and Humarr KhanLujo Virus Hemorrhagic Fever; Janusz T. Paweska, Petrus Jansen van Vuren, and Jacqueline WeyerReceptor Determinants of Zoonosis and Pathogenesis of New World Hemorrhagic Fever Arenaviruses; Stephanie Jemielity, Michael Farzan, and Hyeryun ChoeArgentine Hemorrhagic Fever; Victor Romanowski, Matias L. Pidre, M. Leticia Ferrelli, Cecilia Bender, and Ricardo M. GomezBolivian Hemorrhagic Fever; Sheli R. Radoshitzky, Fabian de Kok-Mercado, Peter B. Jahrling, Sina Bavari, and Jens H. Kuhn"Venezuelan" Hemorrhagic Fever; Sheli R. Radoshitzky, Fabian de Kok-Mercado, Peter B. Jahrling, Sina Bavari, and Jens H. KuhnRift Valley Fever Virus and Hemorrhagic Fever; Alexander N. Freiberg and Ramon FlickCrimean-Congo Hemorrhagic Fever Virus; Onder ErgonulHemorrhagic Fever with Renal Syndrome; Paul Heyman, Tatjana Avsic-Zupanc, Christel Cochez, Ana Saksida, and Ake LundkvistEbola virus Infection; Anthony Griffiths, Andrew Hayhurst, Robert Davey, Olena Shtanko, Ricardo Carrion Jr., and Jean L. PattersonMarburg Virus Disease; Steven B. Bradfute, Sina Bavari, Peter B. Jahrling, and Jens H. KuhnDengue Hemorrhagic Fever; Chwan-Chuen King and Guey Chuen PerngYellow Fever Virus Infection; Kate D. Ryman and William B. KlimstraKyasanur Forest Disease; Gerhard Dobler and Frank HufertAlkhurma Virus Hemorrhagic Fever; Ziad A. Memish, Shamsudeen Fagbo, and Ali ZakiOmsk Hemorrhagic Fever; Daniel Ruzek, Valeriy V. Yakimenko, Lyudmila S. Karan, and Sergey E. TkachevIndex
SUMMARY OR ABSTRACT
Text of Note
Viral hemorrhagic fevers have captured the imagination of the public and made their way into popular books and movies by virtue of their extreme virulence and mysterious origins. Since 2001, concerns have grown about the potential use of many hemorrhagic fever viruses as biological weapons. This has led to a resurgence in research to develop improved diagnostics, vaccines, and therapeutics-both for biodefense purposes and to treat naturally exposed persons. Written by international experts, Viral Hemorrhagic Fevers represents a major contribution to the virological literature and updates the state of knowledge of these dangerous illnesses.Topics include:A historical perspective and information on pathogenesis and immune responsesAnimal models, which are critical to the development of vaccines and therapeuticsThe roles of high-containment facilities and specially trained scientists in researchPrevention and control, including diagnostics and vaccine developmentOld World Lassa and Lujo viruses and the New World Junin and Machupo virusesGuanarito viruses and their cellular receptorsBunyaviruses, including Rift Valley Fever, Crimean- Congo hemorrhagic fever, and hantaviruses that cause hemorrhagic fever with renal syndromeThe Ebola and Marburg filovirusesFlaviviruses, including dengue fever, yellow fever, Kyanasur Forest, Alkhurma, and Omsk hemorrhagic fever viruses and other flaviviruses with hemorrhagic potentialVirologists, clinicians, biomedical researchers, microbiologists, and others needing a rapid overview of the nature of these illnesses will find this book an essential resource on clinical and basic science aspects of many viral hemorrhagic fevers. The book will also provide researchers with a springboard to further inquiry in combating what has become a major global threat.