عنوان

Toll-Like Receptor Family Members and Their Ligands

(Number (ISBN

3642594301

(Number (ISBN

9783642594304

Number

b571303

Title Proper

Toll-Like Receptor Family Members and Their Ligands

General Material Designation

[Book]

First Statement of Responsibility

edited by Bruce Beutler, Hermann Wagner.

Place of Publication, Distribution, etc.

Berlin

Name of Publisher, Distributor, etc.

Heidelberg Springer Berlin Heidelberg

Date of Publication, Distribution, etc.

2002

Specific Material Designation and Extent of Item

(X, 192 p. 6 illus. in color).

Series Title

Current Topics in Microbiology and Immunology, 270

Text of Note

Evolution of the TIR, Tolls and TLRs: Functional Inferences from Computational Biology.-Plant Disease Resistance: Commonality and Novelty in Multicellular Innate Immunity.-Superfamily Signal Transduction Pathways Activated by the IL-1 Receptor/Toll-Like Receptor.-Toll Receptors in Drosophila: A Family of Molecules Regulating Development and Immunity.-Toll-Like Receptors and Their Ligands.-Toll-Like Receptor-5 and the Innate Immune Response to Bacterial Flagellin.-TLR4 as the Mammalian Endotoxin Sensor.-TLR2: Cellular Sensor for Microbial and Endogenous Molecular Patterns.-Bacterial CpG-DNA Licenses TLR9.-MyD88 as a Bottle Neck in Toll/IL-1 Signaling.-Heat Shock Proteins as Ligands of Toll-Like Receptors.-Subject Index.

Text of Note

On occasion, the innate immune system is referred to as the "primitive" immune system. Perhaps this has dissuaded immu­ nologists from analyzing it as energetically as they have analyzed the adaptive immune system during the past two decades. But while its phylogenetic origins are indeed ancient, and though it is "of the first type", there is nothing crude, nothing unsophisti­ cated, and nothing "inferior" about innate immunity. On the contrary, the innate immune system has had time to achieve a level of refinement that is nothing short of dazzling, and a modicum of respect is at long last due. Any immune system has two cardinal functions. It must destroy a broad range of pathogens, and it must spare the host. The adaptive immune system has applied a modular solution to these problems. Each cell of the adaptive immune system is prescreened to eliminate those that would produce untoward interactions with self; each cell is pre-programmed to recognize a foreign epitope that the host might one day encounter. Hence, the duties of each individual lymphocyte are quite circumscribed.

Immunology.

Class number

Book number

edited by Bruce Beutler, Hermann Wagner.

Bruce Beutler

Hermann Wagner

Electronic name

[Book]

Y