Scavenging of Nitric Oxide and Inhibition of its Production
First Statement of Responsibility
edited by Günther Schlag, Heinz Redl.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Berlin, Heidelberg
Name of Publisher, Distributor, etc.
Springer Berlin Heidelberg
Date of Publication, Distribution, etc.
1999
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
(xiv, 293 pages)
CONTENTS NOTE
Text of Note
From the Contents: Inhibition of the Overproduction of Nitric Oxide in Septic Shock Using NG-Methyl-L-Arginine --; Clinical Studies with 546C88 --; Norepinephrine Versus L-NMMA in Hyperdynamic Septic Shock --; Roles for Induced Nitric Oxide in Endotoxic and Hemorrhagic Shock --; Inducible NOS and Other Novel Mediators of Inflammation in Brain Trauma --; Cytokine Control of Nitric Oxide Production: Therapeutic Possibilities --; Inhibition of Nitric Oxide Synthases by the 4-Amino Analogue of Tetrahydrobiopterin --; Effect of Nitric Oxide Inhibitors and Hemoglobin in Sepsis.
SUMMARY OR ABSTRACT
Text of Note
At the Sixth Wiggers Bernard Conference, a group of scientists from various fields discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. This meeting was dedicated to the presentation and discussion of positive and negative findings related to the use of NOS inhibitors, the issue of specific and non-specific inhibitors and the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field. With appropriate dosing and timing the use of NOS inhibitors seems to be beneficial at least in severe sepsis situations, but some inhibitors and overdosing can be potentially dangerous.