Molecular Cloning, Expression, and Characterization of Metabotropic Glutamate Receptor Subtypes. Pharmacological Properties of Metabotropic Glutamate Receptors. Second-Messenger Systems Coupled to Metabotropic Glutamate Receptors in Mammalian Brain. Anatomical Distribution of Metabotropic Glutamate Receptors in Mammalian Brain. Modulation of Ionic Currents by Metabotropic Glutamate Receptors in the CNS. Acute Regulation of Synaptic Transmission by Metabotropic Glutamate Receptors. Long-Lasting Modulation of Synaptic Transmission by Metabotropic Glutamate Receptors. Regulation of Neuronal Circuits and Animal Behavior by Metabotropic Glutamate Receptors. Roles of Metabotropic Glutamate Receptors in Neuronal Degeneration. Plasticity of Metabotropic Glutamate Receptors in Physiological and Pathological Conditions. Index.