عنوان

Biomedical Applications of Proteomics.

(Number (ISBN

1280520760

(Number (ISBN

3527601562

(Number (ISBN

3527605835

(Number (ISBN

6610520763

(Number (ISBN

9781280520761

(Number (ISBN

9783527601561

(Number (ISBN

9783527605835

(Number (ISBN

9786610520763

Number

b563608

Title Proper

Biomedical Applications of Proteomics.

General Material Designation

[Book]

First Statement of Responsibility

Jean-Charles Sanchez

Place of Publication, Distribution, etc.

Hoboken

Name of Publisher, Distributor, etc.

Wiley

Date of Publication, Distribution, etc.

2006

Specific Material Designation and Extent of Item

(465 pages)

Text of Note

5 Unravelling Biological Pathways and the Identification of Clinical Markers and Targets in Renal Cancer.

Text of Note

Biomedical Applications of Proteomics; Contents; List of Contributors; Abbreviations; Introduction; Part I Aspects in Biomedical Research; 1 Proteomics in Biomedicine --; A Tool, a Science, or an Art?; 1.1 Introduction; 1.2 Diagnosis and Prognosis: an Oxymoron; 1.3 The Dimensions of Prognosis; 1.4 Protein Technologies, Diagnosis, and Prognosis; 1.5 Individual Protein Patterns in Clinical Practice; 1.6 New Research Tools, Old Problems; 1.7 What is Human Material?; 1.8 Using Human Tissue in Biomedical Research --; Potential Pitfalls; 1.9 Informed Consent; 1.10 Specificity of Proteomics Studies. 1.11 Conclusion and Summary1.12 Further Reading; Part II Blood Vessels; 2 Antibody-based Vascular Targeting: Proteomic Techniques for the Identification and Quantification of Membrane Proteins on Endothelial Cells; 2.1 Introduction; 2.2 Vascular Targeting; 2.2.1 Angiogenesis; 2.2.2 Angiogenesis-related Disorders; 2.2.3 Markers of Angiogenesis; 2.2.4 Ligand-based Vascular Targeting; 2.3 Technologies for the Quantitation of Membrane Proteins in Different Cell Types; 2.3.1 Gel-based Quantitative Profiling of Membrane Proteins; 2.3.2 Gel-independent Quantitative Profiling of Membrane Proteins. 2.4 Model Systems for the Identification of Vascular Targets2.4.1 In vitro Model Systems for the Study of Gene Expression in Response to Environmental Changes; 2.4.2 In vivo Model Systems for the Identification of Vascular Targets; 2.5 Conclusions; 2.6 Acknowledgements; 2.7 References; 3 Vasculature, Vascular Disease, and Atherosclerosis; 3.1 Introduction; 3.2 Protein Composition of Human Aorta in Atherosclerosis --; Ex vivo Studies; 3.2.1 Cellular Proteins; 3.2.2 Infiltrating Proteins; 3.3 Protein Composition of Human Aorta in Atherosclerosis --; In vitro Studies. 3.4 Lipoproteins and Apolipoproteins as Disease Factors3.4.1 Typing of Apolipoprotein E Phenotype in Humans; 3.4.2 Studies in Transgenic or Knockout Mice; 3.5 Pathogenetic Mechanisms; 3.6 End Pathologies: Myocardial and Cerebral Infarction; 3.7 Surgical Treatments; 3.8 Pharmacological and Dietary Treatments; 3.9 Animal Models of Atherosclerosis and its Complications; 3.10 Conclusions; 3.11 Acknowledgements; 3.12 References; 4 Discovery of New Diagnostic Markers of Stroke; 4.1 Introduction; 4.2 Stroke Features; 4.2.1 Brain Anatomy; 4.2.2 Cerebrovascular Blood Circulation. 4.2.3 Aetiology and Pathology of Stroke4.2.4 Pathophysiology --; Different Types of Stroke; 4.2.5 Epidemiology; 4.2.6 Treatment; 4.3 Current Diagnosis of Stroke; 4.3.1 Physician's Evaluation; 4.3.2 Imaging; 4.3.3 Lumbar Puncture; 4.3.4 Biochemical Markers of Stroke; 4.4 Proteomic-based Approach for the Discovery of Early Diagnostic Stroke Markers; 4.4.1 One-dimensional Gel Electrophoresis; 4.4.2 Two-dimensional Gel Electrophoresis; 4.4.3 SELDI-TOF; 4.5 Conclusions; 4.6 Acknowledgements; 4.7 References; Part III Cancer.

Text of Note

In this first book to provide an overview of applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets, a team of international specialists from research institutions, hospitals and companies contribute with their specific expertise. They cover a wide range of example applications for the most important diseases, such as heart and cardiovascular disorders, cancer, pharmatoxicology, infectious diseases and diseases of the nervous system. Denis Hochstrasser is an eminent scientist in the field of bioinformatics and proteomics and one of the founders of.

Pathology, Molecular -- Therapeutic use.

Proteins.

Proteomics.

Class number

Book number

Jean-Charles Sanchez

Denis F Hochstrasser

Garry L Corthals

Jean-Charles Sanchez

Electronic name

[Book]

Y