عنوان

COX-2 blockade in cancer prevention and therapy

(Number (ISBN

058543882X

(Number (ISBN

159259302X

(Number (ISBN

1617373044

(Number (ISBN

9780585438825

(Number (ISBN

9781592593026

(Number (ISBN

9781617373046

Number

b559890

Title Proper

COX-2 blockade in cancer prevention and therapy

General Material Designation

[Book]

First Statement of Responsibility

edited by Randall E. Harris.

Place of Publication, Distribution, etc.

Totowa, N.J.

Name of Publisher, Distributor, etc.

Humana Press

Date of Publication, Distribution, etc.

©2003.

Specific Material Designation and Extent of Item

(x, 371 pages) : illustrations (some color)

Series Title

Cancer drug discovery and development.

Text of Note

I. Historical Perspectives --;l Dietary Fatty Acids, COX-2 Blockade, and Carcinogenesis --;2 Historical Aspects of COX-2: Cloning and Characterization of the cDNA, Protein and Gene --;II. Epidemiology of NSAIDS and Cancer --;3 Epidemiology of Nonsteroidal Anti-Inflammatory Drugs and Colorectal Cancer --;4 Epidemiology of Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs: Extension of the Dietary Fat Hypothesis of Breast Cancer --;III. Animal Models of Carcinogenesis --;5 Role of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer Prevention --;6 Chemoprevention of Breast Cancer by Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Blockade in Animals --;7 The Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung Cancer --;8 Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc-Driven Intestinal Tumorigenesis --;9 Cyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs --;IV. Molecular Biology of CXO --;10 Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesis --;11 Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2 --;12 Cyclooxygenase-2 and Cancer --;13 Interactions of Cyclooxygenase and Aromatase Pathways in Normal and Malignant Breast Cells --;14 Association of COX-2 and PPARs in Carcinogenesis and Chemoprevention --;15 Carcinogenesis Involving Cyclooxygenase and Lipoxygenase --;V. Clinical Applications --;16 The Development of Drugs that Target Cyclooxygenase-2 --;17 Chemoprevention of Cancer by NSAIDs and Selective COX-2 Blockade --;18 Potential for Inhibitors of Cyclooxygenase-2 to Enhance Tumor Radioresponse --;19 Potential Role of NSAIDs and COX-2 Blockade in Cancer Therapy --;20 Cyclooxygenase-2 Blockade in Cancer Prevention and Therapy: Widening the Scope of Impact.

Text of Note

A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies.

Parallel Title

COX-two blockade in cancer prevention and therapy

Cancer -- Chemoprevention.

Cyclooxygenase 2 -- Inhibitors -- Therapeutic use.

Nonsteroidal anti-inflammatory agents.

Class number

Book number

edited by Randall E. Harris.

Randall E Harris

Electronic name

[Book]

Y