I: Genetic, Growth, and Environmental Factors.- 1 Genetic Evidence for a Novel Familial Alzheimer's Disease Locus on Chromosome 14: Analysis of Candidate Genes.- 2 Growth factors in Parkinson's Disease.- 3 Contribution of Cell Culture to Understanding Neuronal Aging and Degradation.- 4 Neuroepidemiology of Parkinson's Disease: Environmental Influences.- 5 Discussion.- II: Metals and Free Radicals.- 6 Manganese-Induced Neurotoxicity.- 7 Iron and Parkinson's Disease.- 8 Biological Synthesis of Nitric Oxide from L-Arginine.- 9 Multiple Roles of the Calcium Ion in Cell Killing.- 10 Discussion.- III: Energy Metabolism and Neurotoxins.- 11 Mitochondrial Dysfunction, Aging, and Huntington's Disease.- 12 Energy Failure, Glutamate, and Neuropathology: Relevance to Neurodegenerative Disorders.- 13 Proteases and Pathological Neurodegeneration.- 14 Endogenous MPTP-Like Amines in the Brain: Isoquinolines.- 15 Discussion.- IV: Special Topics in Neurodegeneration.- 16 Mitochondrial Disturbances in Parkinson's Disease.- 17 Trophic Factors and Parkinson's Disease.- 18 Spontaneous Generation of Infectious Amyloid Nucleants in the Transmissible and Nontransmissible Brain Amyloidoses.- 19 Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex of Guam: Two Distinct Clinical Entities or a Single Disease Process with a Spectrum of Neuropathological and Clinical Expression?.- 20 Discussion.- Erratum, Volume I, Page 69.