I. Overview: Historical Perspective --;Growth Hormone Releasing Factor: A Brief History of Its Time --;2. Xenobiotic Growth Hormone Secretagogues: Growth Hormone Releasing Peptides --;II. Chemistry of Growth Hormone Secretagogues --;3. Synthetic Analogues of Growth Hormone Releasing Factor (GHRF) with Improved Pharmaceutical Properties --;4. Structure, Function, and Regulation of the Pituitary Receptor for Growth Hormone Releasing Hormone --;5. Computer-Assisted Modeling of Xenobiotic Growth Hormone Secretagogues --;6. Growth Hormone Releasing Peptides --;7. Nonpeptidyl Growth Hormone Secretagogues --;8. A Weak Substance P Antagonist Inhibits L-692,585-Stimulated GH Release in Swine --;9. Growth Hormone Releasing Hormone Receptor in Human Breast Cancer Cell Line MCF-7 --;III. Cellular and Molecular Properties of Growth Hormone Secretagogues --;10. Cellular Physiology of Growth Hormone Releasing Hormone --;11. Mechanism of Action of GHRP-6 and Nonpeptidyl Growth Hormone Secretagogues --;12. Metabolic Regulation of Growth Hormone Secretagogue Gene Expression --;IV. Physiology of Growth Hormone Secretagogues --;13. The Role of Growth Hormone Releasing Hormone (GHRH) and Growth Hormone (GH) in the Onset of Puberty and During Glucocorticoid-Altered Growth --;14. Clinical Studies with Growth Hormone Releasing Hormone --;15. Central and Peripheral Effects of Peptide and Nonpeptide GH Secretagogues on GH Release In Vivo --;16. Evidence for a Central Site and Mechanism of Action of Growth Hormone Releasing Peptide (GHRP-6) --;17. Animal Models for Evaluating Xenobiotic Growth Hormone Secretagogue Activity --;18. A Diagnostic Test Employing Growth Hormone Secretagogues for Evaluating Pituitary Function in the Elderly --;V. Target Tissues and Applications for Growth Hormone Secretagogues --;19. Transdifferentiation of Growth Hormone and Prolactin Secreting Cells --;20. Growth Hormone Releasing Hormone: Behavioral Evidence for Direct Central Actions --;21. Growth Hormone (GH) Releasing Hormone- and Thyrotropin Releasing Hormone-Induced GH Release in the Acute Phase of Trauma --;22. Effects of Hexarelin on Growth Hormone Secretion in Short Normal Children, in Obese Children, and in Subjects with Growth Hormone Deficiency --;23. Lymphocytes and Hypothalamic Peptides --;24. Growth Hormone Releasing Peptide-Hexarelin-in Children: Biochemical and Growth Promoting Effects --;25. Growth Hormone Secretagogues in Disease States Associated with Altered Growth Hormone Secretion --;26. Growth Hormone Releasing Hormone (GHRH) Effects in Healthy Aging Men --;27. Aging and Growth Hormone Releasing Peptides --;28. Growth Hormone Relationships to Immune Function in Humans --;Author Index.
SUMMARY OR ABSTRACT
Text of Note
The work of Dr. Guillemin, who was awarded the 1977 Nobel Prize in Physiology and Medicine, supported the view that quantita- tive change in GH secretion was the net result of pituitary stimulation and inhibition by the hypothalamic neurohormones, GH releasing hormone (GHRH), and somatostatin (somatotropin release inhibiting factor;