Chapter 1 Hedgehog Signaling and Pancreatic Tumor Development Matthias Lauth and Rune Toftgard Chapter 2 The Microenvironment and Molecular Biology of the Multiple Myeloma Tumor Miguel Lemaire, Sarah Deleu, Elke De Bruyne, Els Van Valckenborgh, Eline Menu, and Karin Vanderkerken Chapter 3 Chromatin Insulators: A Role in Nuclear Organization and Gene Expression Jingping Yang and Victor G. Corces Chapter 4 Proteolytic Control of the Oncoprotein Transcription Factor Myc Lance R. Thomas and William P. Tansey Chapter 5 TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade Thierry Soussi