Malignant ventricular arrhythmias and sudden cardiac death.
CONTENTS NOTE
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Abbreviations; Preface; Chapter 1 Epidemiology; What is heart failure?; Systolic heart failure; Diastolic heart failure; The scope of the problem; Incidence; Prevalence; Who is at risk?; Underlying aetiology; Risk of developing heart failure; Effect of ethnicity; Heart failure in the 'developing' world; Morbidity and quality of life; Prognosis; The economic burden of chronic heart failure; Summary; Further reading; Chapter 2 Clinical features; Introduction; Mode of presentation; Symptoms of heart failure; General; Breathlessness; Peripheral oedema; Signs of heart failure. Alterations in the extracellular matrixSummary; Further reading; Chapter 4 Investigations; Introduction; Electrocardiogram; Chest X-ray; Blood tests; Full blood count; Cardiac enzymes and cardiac troponins; Renal function; Liver function and thyroid function; Brain natriuretic peptide; Echocardiography; Nuclear scanning; Magnetic resonance imaging; Cardiac catheterization; Exercise testing; Heart rate variability; Further reading; Chapter 5 Drugs affecting the renin-angiotensin- aldosterone system and diuretics; Introduction; Angiotensin-converting enzyme inhibitors; Mechanism of action. Clinical benefitsAdministration of angiotensin-converting enzyme inhibitors; Ethnicity and ACE inhibition; Adverse effects; Aldosterone escape; Angiotensin II receptor blockers; Aldosterone antagonists; Diuretics; Loop diuretics; Thiazide diuretics; Potassium-sparing diuretics; Adverse effects; Diuretic resistance; Further reading; Chapter 6 Beta-blockers and inotropes; Beta-blockers; Mechanisms of action; Studies of beta-blockers in heart failure; Choice of beta-blocker; Administration; Positive inotropes; Digoxin; Sympathomimetics; Phosphodiesterase inhibitors; Summary; Further reading. Chapter 7 Other vasodilators: nitrates and calcium channel blockersClassification of vasodilators; Principles of vasodilator therapy in heart failure; Nitrates; Mechanism of action; Haemodynamic benefits; Nitrates and heart failure; Nitrate resistance and tolerance; Nicorandil; Calcium channel blockers; Classification and mechanism of action; Calcium channel blockers and heart failure; Summary; Further reading; Chapter 8 Antiarrhythmic and antithrombotic therapy in heart failure; Introduction; Antiarrhythmic drug therapy in heart failure; Atrial fibrillation.