Based on papers presented at an international meeting held in Giessen, FRG in Apr. 1986 as well as some additional contributions.
CONTENTS NOTE
Text of Note
Preface.- Preface.- A Short Historical Review of Spasticity and Its Therapy.- A Short Historical Review of Spasticity and Its Therapy.- Basic Experiences.- Spinal Pharmacology of Agents which Alter Pain Transmission and Muscle Tone.- The Neuropharmacology of Baclofen.- Animal Experiments on the Spinal Action of Midazolam.- Intrathecal Injection of Antispastic Drugs in Rats: Muscle Relaxant Action of Midazolam, Baclofen, 2-Aminophosphonoheptanoic Acid (AP7) and Tizanidine.- CSF Compatibility of Antispastic Agents.- Dural Permeability to Bupivacaine, Baclofen and Midazolam: In Vitro Determination with Human Dura Mater.- Clinical Studies.- Pharmacotherapy of Spasticity.- Pumps in Pharmacotherapy.- Implantation of Ports and Pumps. Technique for Intrathecal Administration of Drugs.- Control of Spasticity with Intrathecal Morphine Sulfate.- Clinical Experience with Spinal Morphine, Midazolam and Tizanidine in Spasticity.- Chronic Intrathecal Baclofen for Severe Rigidity and Spasms.- Intrathecal Baclofen in Spasticity.- Chronic Intrathecal Administration of Baclofen in Treatment of Severe Spasticity.- Pharmacokinetics of Intrathecal Baclofen.- Intrathecal Baclofen in tetanus.- The Value of Spinal Cord Stimulation (SCS) in Treatment of Disorders of the Motor System.- Physostigmine Reversal of Baclofen-induced Sedation.- Surgical Treatment of Spasticity- A Review.